Xu Chunhui, Lin Ren, Bai Ye, Han Yanqiu, Hu Jianda, Hu Jiong, Hu Yu, Huang Fen, Huang Xiaojun, Ji Chunyan, Li Xin, Liang Aibin, Lu Peihua, Ma Jun, Mei Heng, Niu Ting, Ouyang Jian, Qian Wenbin, Shi Jimin, Song Yongping, Sun Aining, Tan Yehui, Wang Hui, Wang Jianxiang, Wang Yu, Wu Depei, Xiao Zhijian, Yang Ting, Zhang Cheng, Zhang Xi, Zhang Xiaohui, Zhao Weili, Zheng Zhuanzhen, Zhu Zunmin, Feng Sizhou, Liu Qifa
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Tianjin 300020, China.
Department of Hematology, Nanfang Hospital, Southern Medical University, Clinical Medical Research Center of Hematological Diseases of Guangdong Province, Guangzhou 510515, China.
Blood Sci. 2025 Aug 29;7(3):e00241. doi: 10.1097/BS9.0000000000000241. eCollection 2025 Sep.
Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases. However, to date, there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders. The Anti-Infection Study Group of the Chinese Society of Hematology invited experts in the fields of hematology, microbiology, and mNGS technology to draft an expert consensus focused on clinical indications, sample collection, quality control, and interpretation of results. This consensus will likely contribute to clarifying the medical indications for mNGS testing, optimizing the interpretation of reports, and becoming an inspiration for global practice.
感染是血液系统疾病患者常见的并发症，病原体诊断仍然具有挑战性。宏基因组下一代测序（mNGS）是一种无偏倚的高通量技术，已广泛应用于传染病诊断。然而，迄今为止，关于使用mNGS诊断血液系统疾病患者感染，尚无既定的国际指南或专家共识。中华医学会血液学分会抗感染学组邀请血液学、微生物学和mNGS技术领域的专家起草了一份专家共识，重点关注临床指征、样本采集、质量控制和结果解读。该共识可能有助于明确mNGS检测的医学指征，优化报告解读，并为全球实践提供借鉴。
