Emergency Department, University Hospitals of Derby and Burton NHS Foundation Trust, Royal Derby Hospital, Derby DE22 3NE, UK
University of Nottingham School of Medicine, Nottingham, UK.
BMJ. 2020 Dec 10;371:m4467. doi: 10.1136/bmj.m4467.
To analyse the therapeutic effects and toxicity of the eponymous concoction described in Roald Dahl's book .
Literature review.
Two literature loving households in England.
George Kranky and grandma Kranky.
Clinical and toxic effects of the individual ingredients checked against those listed in ToxBase, the National Poisons Information Service's poisons database.
The medicine contained 34 ingredients. The most common toxic effect identified on ToxBase was nausea and vomiting (16 ingredients, 47%). Potentially life threatening effects were associated with 13 (38%) ingredients, including depression of the central nervous system, kidney injury, convulsions, cardiac toxicity, and mucosal erosion. The effects described in the book were accurate initially but then diverted from the most likely clinical outcome (death).
Although Dahl ought to be applauded for his initial accuracy about the toxicology of the ingredients in George's marvellous medicine, the overall effect would be fatal catastrophic physiological collapse. Scientific exploration and experimentation should be encouraged in children, although any medicinal ingredients need to be checked for potential toxicity before being administered-to grandmas or anyone else.
分析罗尔德·达尔（Roald Dahl）书中同名方剂的治疗效果和毒性。
文献回顾。
英国两个热爱文学的家庭。
乔治·克兰基（George Kranky）和克兰基奶奶（Grandma Kranky）。
逐一检查个体成分的临床和毒性作用，与 ToxBase（国家毒物信息服务毒物数据库）中列出的成分进行对照。
该药物包含 34 种成分。ToxBase 中最常见的毒性作用是恶心和呕吐（16 种成分，占 47%）。与 13 种（38%）成分相关的潜在危及生命的影响包括中枢神经系统抑制、肾损伤、惊厥、心脏毒性和黏膜侵蚀。书中描述的最初效果与毒理学成分准确相符，但随后偏离了最可能的临床结果（死亡）。
尽管达尔（Dahl）最初准确描述了乔治（George）那神奇药物中成分的毒理学特性值得称赞，但总体效果将是致命的灾难性生理崩溃。应该鼓励儿童进行科学探索和实验，但在给药之前，需要检查任何药用成分的潜在毒性——无论是给奶奶还是其他人。
