Alotaibi Saad H, Amer Hamada H
Department of Chemistry, University College of Turabah, Taif University, P.O. Box 11099, Taif 21944, Saudia Arabia.
Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Egypt.
Saudi J Biol Sci. 2020 Dec;27(12):3481-3488. doi: 10.1016/j.sjbs.2020.09.061. Epub 2020 Oct 16.
New Nucleosides, analogues derived from 1, 3, 4-oxadiazole, arylidene analogues and α-aminophosphonate were prepared. Infrared (IR), elemental analysis and HNMR elucidated nucleosides; arylidines and phosphonate derivatives. The prepared derivatives were purified and allowed to test against bacteria strains. Phosphonate derivative showed the higher antibacterial against with inhibition zone 35 mm, P. aeruginosa with inhibition zone 30 and S. aureus with inhibition zone 22 while compounds , , , and showed moderate to weak activity against these bacteria species with inhibition zones ranged from 12 mm to 24 mm. The molecular docking studies was applied on compound , which showed the binding at the active DNA Gyrase.
制备了新型核苷、源自1,3,4-恶二唑的类似物、亚芳基类似物和α-氨基膦酸酯。通过红外光谱（IR）、元素分析和核磁共振氢谱（HNMR）对核苷、亚芳基和膦酸酯衍生物进行了表征。对制备的衍生物进行纯化，并对细菌菌株进行测试。膦酸酯衍生物对[具体细菌名称未给出]表现出较高的抗菌活性，抑菌圈为35毫米，对铜绿假单胞菌抑菌圈为30毫米，对金黄色葡萄球菌抑菌圈为22毫米，而化合物[具体化合物编号未给出]对这些细菌物种表现出中度至弱的活性，抑菌圈范围为12毫米至24毫米。对化合物[具体化合物编号未给出]进行了分子对接研究，结果表明该化合物与活性DNA促旋酶结合。
