Susskind H, Brill A B, Harold W H
Medical Research Center, Brookhaven National Laboratory, Upton, New York 11973.
Am J Physiol Imaging. 1986;1(2):67-76.
Regional distributions of deposited Tc-99m diethylenetriamine pentaacetate aerosol (DPTA) and of Kr-81m were compared in the upright lungs of 22 coal miners with nonembolic pulmonary disease. Pixel-by-pixel distributions of Kr-81m and DPTA corrected for lung volume, as well as DTPA/Kr-81m ratios, were determined by computer analysis in each lung and plotted against lung position. DTPA was preferentially deposited in the basal regions of 36/44 lungs. In the same lungs, Kr-81m was preferentially distributed in the apical regions of 18 lungs, bilaterally in six subjects. Similar DTPA and Kr-81m regional distributions throughout both lungs were obtained in only 11 (50%) subjects. No significant correlations were found between regional particle deposition and pulmonary function measurements. The effects of gravity-related lung pressure gradients and ventilation-related particle residence time on the deposition of DTPA may limit its usefulness when quantitative information is required to evaluate subtle changes in ventilation in nonembolic pulmonary patients and for basic studies of ventilation and perfusion.
比较了22例患有非栓塞性肺部疾病的煤矿工人直立位肺中沉积的锝-99m二乙三胺五乙酸气雾剂（DPTA）和氪-81m的区域分布。通过计算机分析确定每个肺中经肺体积校正后的氪-81m和DPTA的逐像素分布以及DTPA/氪-81m比值，并将其与肺位置相对应绘制。DPTA优先沉积在44个肺中的36个肺的基底区域。在同一批肺中，氪-81m优先分布在18个肺的尖部区域，在6名受试者中为双侧分布。仅在11名（50%）受试者的双肺中获得了相似的DPTA和氪-81m区域分布。未发现区域颗粒沉积与肺功能测量之间存在显著相关性。重力相关的肺压力梯度和通气相关的颗粒停留时间对DTPA沉积的影响可能会限制其在评估非栓塞性肺部疾病患者通气的细微变化以及进行通气和灌注基础研究时，在需要定量信息时的实用性。
