Fazio F, Wollmer P, Lavender J P, Barr M M
J Nucl Med. 1982 Apr;23(4):306-14.
Following routine ventilation (Kr-81m)/perfusion (Tc-99m) scanning, we obtained aerosol ventilation scans using a solution of In-113m albumin and a settling-bag system. The large-volume settling bag reduces deposition of particles in the large airway by removing large droplets. The patient inhales the aerosol with 5-10 min of tidal breathing, then lung scans are obtained on a gamma camera. The energy of In-113m allows the ventilation scanning to be performed after Tc-99m perfusion scanning. Semiquantitative scoring of regional ventilation showed a close correlation (r = 0.97) between Kr-81m and In-113m aerosol ventilation scans. The aerosol technique gave a slight underestimation of ventilation compared with Kr-81m. This is explained by a slightly reduced penetration of particles to the periphery of the lung in patients with severe obstructive airways disease. In all cases, however, the aerosol did visualize all ventilated regions. The results indicate that this readily available aerosol technique can be useful for clinical ventilation imaging in multiple views.
在进行常规通气（Kr-81m）/灌注（Tc-99m）扫描后，我们使用In-113m白蛋白溶液和沉降袋系统获得了气溶胶通气扫描图像。大容量沉降袋通过去除大液滴减少了颗粒在大气道中的沉积。患者通过5 - 10分钟的潮式呼吸吸入气溶胶，然后在γ相机上进行肺部扫描。In-113m的能量使得通气扫描能够在Tc-99m灌注扫描之后进行。区域通气的半定量评分显示，Kr-81m和气溶胶通气扫描之间存在密切相关性（r = 0.97）。与Kr-81m相比，气溶胶技术对通气的估计略有低估。这可以解释为在患有严重阻塞性气道疾病的患者中，颗粒向肺周边的穿透略有减少。然而，在所有情况下，气溶胶都能显示出所有通气区域。结果表明，这种易于获得的气溶胶技术可用于多视角的临床通气成像。
