天然抗氧化剂在肝脏缺血再灌注损伤实验动物模型中的应用。
Use of natural anti-oxidants in experimental animal models of hepatic ischemia-reperfusion injury.
作者信息
Kyriakopoulos Georgios, Valsami Georgia, Tsalikidis Christos, Pitiakoudis Michail, Tsaroucha Alexandra K
机构信息
Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
School of Health Sciences, Department of Pharmacy, National and Kapodistrian University of Athens, Greece.
出版信息
Ann Med Surg (Lond). 2020 Nov 26;60:592-599. doi: 10.1016/j.amsu.2020.11.061. eCollection 2020 Dec.
BACKGROUND
Ischemia-reperfusion injury (IRI) remains a clinical challenge in liver surgery, trauma and transplantation, contributing to morbidity and mortality worldwide. Thus, its impact, not only on the liver itself but also on remote tissues, has been studied during the last years. Different natural anti-oxidant substances have been researched in animal models, implementing different times of ischemia, aiming to test new therapeutic interventions.
OBJECTIVE
A literature review has been conducted with two goals: (1) to identify different natural anti-oxidants studied in experimental models; and (2) to summarize the various times of ischemia employed.
METHODS
Scientific papers published in PubMed for the period 2000-2020 were searched and reviewed.
RESULTS
More than 30 natural anti-oxidants have been tested. The time of ischemia ranged from 15 to 90 min with 60 min used most frequently, followed by 45 min. No studies were found with time exceeding 90 min.
CONCLUSIONS
A significant number of research has been conducted on the use and protective effect of natural anti-oxidants in experimental animal models. Based on the published papers, 45-60 min seems to be the optimal duration of ischemia.
背景
缺血再灌注损伤（IRI）仍是肝脏手术、创伤和移植领域的一项临床挑战，在全球范围内导致发病率和死亡率上升。因此，近年来人们对其不仅对肝脏本身，而且对远处组织的影响进行了研究。在动物模型中研究了不同的天然抗氧化物质，采用了不同的缺血时间，旨在测试新的治疗干预措施。
目的
进行了一项文献综述，有两个目标：（1）确定在实验模型中研究的不同天然抗氧化剂；（2）总结所采用的不同缺血时间。
方法
检索并综述了2000年至2020年期间发表在PubMed上的科学论文。
结果
已测试了30多种天然抗氧化剂。缺血时间从15分钟到90分钟不等，最常使用的是60分钟，其次是45分钟。未发现缺血时间超过90分钟的研究。
结论
在实验动物模型中，已经对天然抗氧化剂的使用和保护作用进行了大量研究。根据已发表的论文，45 - 60分钟似乎是缺血的最佳持续时间。
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