Mathieu D, Jacques L, Auer J, Bizzini B
Service de Microbiologie, Hôpital Paul-Brousse, Villejuif, France.
Biomed Pharmacother. 1987;41(8):442-5.
The preventive effects of the immunomodulator P40 on the experimental E. coli infection of the lower urinary tract of the rat have been reported previously. In the present paper are presented the results obtained with the aid of vaccination using the same experimental model of infection in the rat. Active specific immunization of the animals with a vaccine consisting of the same strain as that used for infecting the rats afforded significant protection toward the infection. It is concluded that such vaccines could also be used in humans, either alone or in combination with other therapies with the aim at preventing recurrencies or relapses of infections of the lower urinary tract which were resistant to antibiotherapy.
免疫调节剂P40对大鼠下尿路感染的预防作用此前已有报道。本文介绍了在大鼠相同感染实验模型中通过接种疫苗获得的结果。用与感染大鼠相同菌株组成的疫苗对动物进行主动特异性免疫，可对感染提供显著保护。得出的结论是，此类疫苗也可单独或与其他疗法联合用于人类，以预防对抗生素治疗耐药的下尿路感染的复发或再发。
