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一种新型主动脉瓣支架的有限元分析

Finite Element Analysis of a Novel Aortic Valve Stent.

作者信息

Castravete Ştefan, Mazilu Dumitru, Gruionu Lucian Gheorghe, Militaru Cristian, Militaru Sebastian, UdriŞtoiu Anca-Loredana, Iacob Andreea Valentina, Gruionu Gabriel

机构信息

Caelynx Europe Ltd., Craiova, Romania.

National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

出版信息

Curr Health Sci J. 2020 Jul-Sep;46(3):290-296. doi: 10.12865/CHSJ.46.03.11. Epub 2020 Sep 30.

DOI:10.12865/CHSJ.46.03.11
PMID:33304631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7716760/
Abstract

Worldwide, one of the leading causes of death for patients with cardiovascular disease is aortic valve failure or insufficiency as a result of calcification and cardiovascular disease. The surgical treatment consists of repair or total replacement of the aortic valve. Artificial aortic valve implantation via a percutaneous or endovascular procedure is the minimally invasive alternative to open chest surgery, and the only option for high-risk or older patients. Due to the complex anatomical location between the left ventricle and the aorta, there are still engineering design optimization challenges which influence the long-term durability of the valve. In this study we developed a computer model and performed a numerical analysis of an original self-expanding stent for transcatheter aortic valve in order to optimize its design and materials. The study demonstrates the current valve design could be a good alternative to the existing commercially available valve devices.

摘要

在全球范围内，心血管疾病患者的主要死因之一是由于钙化和心血管疾病导致的主动脉瓣功能衰竭或关闭不全。手术治疗包括主动脉瓣修复或完全置换。通过经皮或血管内手术植入人工主动脉瓣是开胸手术的微创替代方案，也是高危或老年患者的唯一选择。由于左心室和主动脉之间复杂的解剖位置，仍存在工程设计优化挑战，这会影响瓣膜的长期耐用性。在本研究中，我们开发了一个计算机模型，并对一种用于经导管主动脉瓣的新型自膨胀支架进行了数值分析，以优化其设计和材料。该研究表明，当前的瓣膜设计可能是现有商用瓣膜装置的一个很好的替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/5e9cd5366667/CHSJ-46-03-290-fig7b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/2cde8322eb8d/CHSJ-46-03-290-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/6bcf55247e76/CHSJ-46-03-290-fig2c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/ee555b82e854/CHSJ-46-03-290-fig2e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/6e7ca2346ea6/CHSJ-46-03-290-fig2f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/77bbffce21b0/CHSJ-46-03-290-fig3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/ab6f2e5f4cda/CHSJ-46-03-290-fig3b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/9ff36fdc359c/CHSJ-46-03-290-fig3c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/94a8640fdf45/CHSJ-46-03-290-for1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/534b17df0639/CHSJ-46-03-290-for2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/b2154f24fdf7/CHSJ-46-03-290-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/eb9982064f86/CHSJ-46-03-290-for3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/0db358572fdf/CHSJ-46-03-290-fig5a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/256fc2bee79a/CHSJ-46-03-290-fig5b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/279f8f80a081/CHSJ-46-03-290-fig5c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/5c227cecf08b/CHSJ-46-03-290-fig5d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/b33766a9deeb/CHSJ-46-03-290-fig6a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/f52c92e14f58/CHSJ-46-03-290-fig6b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/3d81fd9e0278/CHSJ-46-03-290-fig6c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/31dd8cd2a550/CHSJ-46-03-290-fig6d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/ff2d83194814/CHSJ-46-03-290-fig7a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/7716760/5e9cd5366667/CHSJ-46-03-290-fig7b.jpg

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Hemodynamic effects of support modes of LVADs on the aortic valve.左心室辅助装置支持模式对主动脉瓣的血流动力学影响。
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Novel stent design for transcatheter mitral valve implantation.用于经导管二尖瓣植入的新型支架设计
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