Brush Layer Charge Characteristics of a Biomimetic Polyelectrolyte-Modified Nanoparticle Surface.

Nanoparticle surface charge regulation technology plays an important role in ion rectification, drug delivery, and cell biology. The biomimetic polyelectrolyte can be combined with nanoparticles by nanomodification technology to form a layer of coating, which is called the brush layer of nanoparticles. In this study, based on the Poisson-Nernst-Planck (PNP) equation system, a theoretical model considering a bionic electrolyte brush layer with charge density regulated by a chemical reaction is constructed. The charge properties of brushed nanoparticles are studied by changing the sizes of nanoparticles, the pH value of the solution, background salt solution concentration, and brush layer thickness. The result shows that the charge density of brushed nanoparticles increases with the increase of particle size. The isoelectric point (IEP) of the equilibrium reaction against the brush layer is pH = 5.5. When the pH < 5.5, the charge density of the particle brush layers decreases with the increase of pH, and when the pH > 5.5, the charge density of the particle brush layer increases with the increase of pH. By comparing the charge density of different brush thicknesses, it is found that the larger the brush thickness, the smaller the charge density of the brush layer. This research provides theoretical support for the change of the through pore velocity when macromolecular organic compounds pass through nanopores.