University of Ioannina, Niacrhos Avenue, Ioannina, 45 000, Greece.
European School of Oncology College, 20121, Milan, Italy.
Future Oncol. 2021 Jan;17(2):151-157. doi: 10.2217/fon-2020-0677. Epub 2020 Dec 11.
To report on the management strategies in patients with cancer of unknown primary (CUP) in middle-income countries. We conceived a survey of 20 items concerning the management of patients with CUP in daily clinical practice. Only participants from lower- and higher-middle-income countries, as per the World Bank Classification, were eligible for this study. The indications for the first-line treatment did not differ between the two economic regions, whereas those for second-line treatment were more prevalent in higher-middle-income countries. The use of targeted therapy based on immunohistochemistry alone was higher in lower-middle-income countries, although the access to CUP classifiers was similar between the two regions. Proper recommendations must ensure that the economic burden is minimized and that other benefits outweigh the limited survival benefit achieved in patients with CUP.
报告中介绍了中低收入国家中癌症未知原发灶（CUP）患者的管理策略。我们设计了一项包含 20 个项目的调查，内容涉及 CUP 患者在日常临床实践中的管理。只有来自世界银行分类中低收入和中高收入国家的参与者才有资格参加这项研究。一线治疗的指征在两个经济区域之间没有差异，而二线治疗的指征在中高收入国家更为常见。单纯基于免疫组织化学的靶向治疗在中低收入国家更为常见，尽管两个区域获得 CUP 分类器的途径相似。适当的建议必须确保将经济负担降到最低，并且其他益处超过 CUP 患者有限的生存获益。
