The independent and joint associations between muscle strength, health variables and cardiovascular disease among adults.

OBJECTIVES

We investigated the independent and joint association between muscle strength and health variables according to individual health status among adults.

METHODS

Cross-sectional population-based study comprising 643 adults (39.6 ± 11.1 years, 44.9% men) from Florianópolis, Southern Brazil. Muscle strength was assessed by handgrip strength. Health variables included were systolic (SBP) and diastolic blood pressure (DBP), waist circumference (WC), carotid intima-media thickness (IMT), high-sensitivity C-reactive protein (CRP), total cholesterol (CHOL), HDL cholesterol (HDL-C), triglycerides (TRG), glycated hemoglobin (HbA1c), and insulin resistance index (HOMA-IR). Participants were grouped into three health status categories: 1) healthy (without CVD and risk for CVD); 2) at risk for CVD (obesity, high blood pressure, and hyperglycemia); 3) with CVD. Multiple linear regression adjusted for confounding factors was used.

RESULTS

Muscle strength was inversely associated with IMT (β = -0.02, SE: 0.03), CHOL (β = -0.14, SE: 0.02) and HbA1c (β = -0.01, SE: 0.10), and directly associated with SBP (β = 0.16, SE: 0.06) and WC (β = 0.02, SE: 0.03). Among adults with CVD, muscle strength was inversely associated with IMT (p < 0.05). Higher muscle strength was directly associated with SBP among healthy adults (p < 0.05).

CONCLUSION

The main finding of the present study indicated that among individuals with CVD, muscle strength was associated with lower IMT values.