Research Center in Kinanthropometry and Human Performance, Federal University of Santa Catarina, Florianopolis, Brazil.
Discipline of General Practice, Adelaide Medical School, The University of Adelaide, Adelaide, Australia.
Eur J Sport Sci. 2022 Jul;22(7):1122-1131. doi: 10.1080/17461391.2021.1902571. Epub 2021 Apr 2.
The aim of the present study was to investigate the independent and joint associations among muscle strength (MS) and obesity with blood pressure, atherosclerosis, and laboratory markers. This was a cross-sectional study comprising a representative sample of 642 adults (men: 44.9%, 39.9 ± 11.2 years; women: 55.1%, 39.3 ± 11.1 years) from Florianópolis, Brazil. MS was assessed by handgrip strength. Obesity was defined as a Body Mass Index (BMI) ≥30.0 kg/m² and a waist circumference ≥80.0 cm in women and ≥90.0 cm in men. Clinical variables included systolic (SBP) and diastolic blood pressure (DBP), C-reactive protein (CRP), lipids, glucose metabolism markers and carotid intima-media thickness (IMT). Linear regression models stratified by sex and adjusted for confounders were used. Higher MS levels were related to lower CRP (up to 0.59 times lower), triglycerides (up to 0.33 times lower), HOMA-IR (up to 0.35 times lower), and higher HDL cholesterol (up to 5.2 mg/dL) levels among men. Among women, higher MS levels were related to lower SBP and DBP (up to -10.2 mmHg), CRP (up to 0.56 times lower), HOMA-IR (up to 0.27 times lower) and IMT (up to -4.8 × 10 mm). In addition, MS was inversely related to triglycerides and HOMA-IR among obese men, inversely related to CRP among obese men and women, and inversely associated to DBP only among obese women. This population-based study corroborates findings from clinical studies suggesting that even among individuals with obesity, higher MS might help adults to reduce cardiometabolic risk. HighlightsMuscle strength levels were directly associated with better prognosis in relation to cardiometabolic variables in individuals with or without abdominal obesity.Among men with abdominal obesity, to have higher values of muscle strength were associated with lower values of diastolic blood pressure, C-reactive protein, triglycerides, cholesterol and HOMA-IR.Higher muscle strength levels were inversely associated with C-reactive protein among women with abdominal obesity; Higher muscle strength might help adults to reduce cardiometabolic risk.
本研究旨在探讨肌肉力量（MS）和肥胖与血压、动脉粥样硬化和实验室标志物之间的独立和联合关联。这是一项横断面研究，纳入了巴西弗洛里亚诺波利斯的 642 名成年人（男性：44.9%，39.9±11.2 岁；女性：55.1%，39.3±11.1 岁）作为代表性样本。MS 通过握力评估。肥胖定义为体重指数（BMI）≥30.0kg/m²和女性腰围≥80.0cm，男性腰围≥90.0cm。临床变量包括收缩压（SBP）和舒张压（DBP）、C 反应蛋白（CRP）、血脂、葡萄糖代谢标志物和颈动脉内膜中层厚度（IMT）。使用按性别分层并调整混杂因素的线性回归模型。在男性中，更高的 MS 水平与更低的 CRP（低至 0.59 倍）、甘油三酯（低至 0.33 倍）、HOMA-IR（低至 0.35 倍）和更高的高密度脂蛋白胆固醇（高至 5.2mg/dL）水平相关。在女性中，更高的 MS 水平与更低的 SBP 和 DBP（低至-10.2mmHg）、CRP（低至 0.56 倍）、HOMA-IR（低至 0.27 倍）和 IMT（低至-4.8×10mm）相关。此外，在肥胖男性中，MS 与甘油三酯和 HOMA-IR 呈负相关，在肥胖男性和女性中与 CRP 呈负相关，仅在肥胖女性中与 DBP 呈负相关。这项基于人群的研究证实了临床研究的发现，即在存在或不存在腹部肥胖的个体中，更高的 MS 可能有助于成年人降低心血管代谢风险。
