Dana-Farber Cancer Institute, Boston, Massachusetts.
Boston Children's Hospital, Boston, Massachusetts.
Pediatr Blood Cancer. 2021 May;68(5):e28847. doi: 10.1002/pbc.28847. Epub 2020 Dec 11.
Corticosteroids are essential to treating childhood acute lymphoblastic leukemia (ALL), and can cause significant neuropsychiatric side effects. This retrospective chart review is a preliminary exploration of characteristics associated with psychiatry consultation and steroid-induced affective disorder (SIAD) during ALL treatment. Of 125 ALL patients (ages 1-10 years), 56 (44.8%) received psychiatry consultation. Thirty-nine (31.2%) of the total cohort were diagnosed with SIAD. SIAD was significantly associated with family psychiatric history, but not with steroid exposure, CNS radiation, sociodemographic factors, developmental delay, Trisomy 21, or prior psychiatric history. Gathering family psychiatric history may help identify children at increased risk of SIAD.
皮质类固醇是治疗儿童急性淋巴细胞白血病（ALL）的关键药物，但也会导致显著的神经精神副作用。本回顾性图表研究初步探索了 ALL 治疗过程中与精神科咨询和类固醇引起的情感障碍（SIAD）相关的特征。在 125 名 ALL 患儿（1-10 岁）中，有 56 名（44.8%）接受了精神科咨询。总队列中有 39 名（31.2%）被诊断为 SIAD。SIAD 与家族精神病史显著相关，但与类固醇暴露、中枢神经系统放疗、社会人口学因素、发育迟缓、21 三体或既往精神病史无关。收集家族精神病史可能有助于识别 SIAD 风险增加的患儿。
