Samsel Chase, Muriel Anna C
Department of Psychiatry, Boston Children's Hospital, Boston, Massachusetts.
Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts.
Pediatr Blood Cancer. 2017 Feb;64(2):343-345. doi: 10.1002/pbc.26220. Epub 2016 Sep 12.
Treatment of pediatric acute lymphoblastic leukemia (ALL) relies on systemic corticosteroids for remission; however, they can cause significant mood and behavior changes that interfere with quality of life and may increase risk for injury. This case series reports on preschool children with preexisting developmental and psychiatric risk factors who presented with behavioral side effects that required intervention. Identification of these vulnerable children may provide opportunities for early intervention, anticipatory guidance, and effective treatment to minimize behavioral side effects and improve quality of life and safety during ALL treatment.
小儿急性淋巴细胞白血病（ALL）的治疗依赖全身使用皮质类固醇来实现缓解；然而，它们可能会导致显著的情绪和行为变化，干扰生活质量，并可能增加受伤风险。本病例系列报告了患有发育和精神疾病风险因素的学龄前儿童，这些儿童出现了需要干预的行为副作用。识别这些易受影响的儿童可能为早期干预、预期指导和有效治疗提供机会，以尽量减少行为副作用，提高ALL治疗期间的生活质量和安全性。
