Division of Maternal Fetal Medicine, Nemours Children's Hospital, Orlando, Florida.
Clin Obstet Gynecol. 2021 Mar 1;64(1):214-225. doi: 10.1097/GRF.0000000000000584.
Pregnant women with obesity are at increased risk of a multitude of complications of pregnancy and adverse perinatal outcomes. The risk of some of these complications, such as neural tube defects or preeclampsia, may be mitigated by some medications. Other complications, such as diabetes, venous thromboembolism, and infections, require treatment with medications. Given the changes in pharmacokinetics and pharmacodynamics during pregnancy, which is further enhanced by obesity, the optimal medication and its dose is often researched. This chapter further explores the different complications and common medications that women with obesity are likely to require.
肥胖孕妇妊娠并发症和不良围产结局的风险增加。一些并发症的风险，如神经管缺陷或子痫前期，可能通过一些药物得到缓解。其他并发症，如糖尿病、静脉血栓栓塞和感染，需要药物治疗。由于肥胖进一步增强了妊娠期间药代动力学和药效学的变化，因此经常需要研究最佳药物及其剂量。本章进一步探讨了肥胖女性可能需要的不同并发症和常见药物。
