Sarter M
Research Laboratories of Schering AG, Berlin (West), Federal Republic of Germany.
Compr Gerontol A. 1987 Feb;1(1):4-15.
Six animal models of human brain ageing or of age-related diseases, especially Alzheimer's disease, are evaluated. Special emphasis is laid on comparing the neuropathological symptoms found in aged human brains or in Alzheimer patients, with the neuronal symptoms induced experimentally by the different treatments described here. For each model, the experimental methods for induction of the neuropathological symptoms (lipofuscin accumulation, senile plaques, neurofibrillary degeneration, etc.) and for their identification are discussed. In addition, the behavioral significance of each animal model is evaluated in the content of its meaning for cognitive alterations in senescence or in dementia.
对六种人类大脑衰老或与年龄相关疾病（尤其是阿尔茨海默病）的动物模型进行了评估。特别强调将在老年人类大脑或阿尔茨海默病患者中发现的神经病理学症状，与此处描述的不同治疗方法实验性诱导的神经元症状进行比较。对于每种模型，都讨论了诱导神经病理学症状（脂褐素积累、老年斑、神经原纤维变性等）及其识别的实验方法。此外，根据每种动物模型对衰老或痴呆中认知改变的意义，评估其行为学意义。
