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[正常衰老、阿尔茨海默病和额颞叶痴呆中的执行功能缺陷]

[Executive function deficits in normal aging, Alzheimer's disease, and frontotemporal dementia].

作者信息

Bherer Louis, Belleville Sylvie, Hudon Carol

机构信息

Centre de recherche, Institut universitaire de gériatrie de Montréal.

出版信息

Psychol Neuropsychiatr Vieil. 2004 Sep;2(3):181-9.

Abstract

An increasing number of studies suggest that executive functions are among the first cognitive functions to bear negative effects of normal aging. Executive functions also appear to be early affected in Alzheimer's disease and frontotemporal dementia. This article reviews studies in neuropsychology and experimental cognitive psychology with a focus on normal aging, Alzheimer's disease as well as frontotemporal dementia. Study results suggest that so called executive tasks are not equally impaired by normal ageing or dementia in agreement with the recent theoretical models, which state that a set of distinct elementary mechanisms subserve the executive control of cognitive behavior. These models are therefore particularly relevant to address issues stemming from aging.

摘要

越来越多的研究表明,执行功能是最早受到正常衰老负面影响的认知功能之一。在阿尔茨海默病和额颞叶痴呆中,执行功能似乎也会较早受到影响。本文综述了神经心理学和实验认知心理学方面的研究,重点关注正常衰老、阿尔茨海默病以及额颞叶痴呆。研究结果表明,与最近的理论模型一致,所谓的执行任务在正常衰老或痴呆中受到的损害并不相同,这些理论模型指出,一组不同的基本机制有助于对认知行为进行执行控制。因此,这些模型对于解决由衰老引发的问题尤为重要。

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