Department of Psychiatry, Okehazama Hospital, Aichi, Japan; Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan.
Department of Epidemiology, Nara Medical University School of Medicine, Nara, Japan.
Physiol Behav. 2021 Mar 1;230:113281. doi: 10.1016/j.physbeh.2020.113281. Epub 2020 Dec 8.
Obesity and overweight are highly prevalent in individuals with bipolar disorder and are associated with a risk of developing not only physical but also mental problems. The current study aimed to determine the association between bedroom light exposure at night and obesity in individuals with bipolar disorder. This cross-sectional study enrolled 200 outpatients with bipolar disorder. The light intensity in the bedroom between bedtime and rising time was measured for seven consecutive nights using a portable photometer. Body mass index (BMI) was determined using self-reported height and weight, and obesity was defined as a BMI ≥ 25 kg/m. The overall prevalence of obesity was 44%. In the multivariable logistic regression analysis adjusted for age, gender, use of psychiatric medications, sleep parameters, and physical activity, the odds ratio (OR) for obesity was significantly higher in the group exposed to an average light intensity ≥ 3 lux (n = 112) than in the group exposed to an average light intensity < 3 lux (n = 88) (OR, 2.13; 95% confidence interval, 1.19-4.21; P = 0.01). Furthermore, individuals exposed to an average light intensity ≥ 3 lux were significantly higher body weight (adjusted mean, 68.7 vs. 64.4 kg; P = 0.03) and BMI (adjusted mean, 25.6 vs. 24.2 kg/m; P = 0.04) than those exposed to an average light intensity < 3 lux. A significant association was observed between bedroom light exposure at night and obesity in patients with bipolar disorder. Further longitudinal investigations are necessary to clarify this association.
肥胖和超重在双相情感障碍患者中非常普遍，并且与不仅身体而且精神问题的风险相关。本研究旨在确定夜间卧室光暴露与双相情感障碍患者肥胖之间的关系。这项横断面研究纳入了 200 名门诊双相情感障碍患者。使用便携式光度计连续七天测量睡眠时间和起床时间之间卧室的光强度。使用自我报告的身高和体重确定体重指数（BMI），并将 BMI≥25kg/m 定义为肥胖。肥胖的总体患病率为 44%。在调整年龄、性别、使用精神药物、睡眠参数和体力活动后，多变量逻辑回归分析显示，暴露于平均光强度≥3lux 的组（n=112）肥胖的比值比（OR）明显高于暴露于平均光强度<3lux 的组（n=88）（OR，2.13；95%置信区间，1.19-4.21；P=0.01）。此外，暴露于平均光强度≥3lux 的个体体重（调整后的平均值，68.7 与 64.4kg；P=0.03）和 BMI（调整后的平均值，25.6 与 24.2kg/m；P=0.04）明显高于暴露于平均光强度<3lux 的个体。夜间卧室光暴露与双相情感障碍患者肥胖之间存在显著关联。需要进一步的纵向研究来阐明这种关联。
