Read A P
Department of Medical Genetics, St Mary's Hospital, Manchester.
Dis Markers. 1986 Jun;4(1-2):59-66.
The use of heritability studies, haplotype sharing, and lod score analysis are reviewed. Twin and family studies show that any genes conferring susceptibility to rheumatoid arthritis must have a relatively low penetrance. This is a serious obstacle to linkage analysis in families. Where there is a population association, as with DR4, studies of haplotype sharing by affected sibs may yield more information if the observations are compared with the sharing predicted from the population association.
本文回顾了遗传度研究、单倍型共享及连锁分析计分法的应用。双胞胎及家族研究表明，任何赋予类风湿性关节炎易感性的基因，其外显率必然相对较低。这是家族连锁分析的一个严重障碍。在存在人群关联的情况下，如与DR4相关，若将受累同胞的单倍型共享观察结果与基于人群关联所预测的共享情况进行比较，可能会获得更多信息。
