类风湿关节炎的家族研究——HLA - DR4及自身免疫性甲状腺疾病相关基因的重要性。
Family studies in RA - the importance of HLA-DR4 and of genes for autoimmune thyroid disease.
作者信息
Grennan D M, Dyer P A, Clague R, Dodds W, Smeaton I, Harris R
出版信息
J Rheumatol. 1983 Aug;10(4):584-9.
The segregation of HLA haplotypes with rheumatoid arthritis (RA) was studied in 13 selected, multicase families. HLA-DR4 was present in 77% of RA probands (32% controls). No single haplotype was associated with RA in different families. Analysis of HLA haplotype sharing in affected relatives showed no significant difference to the expected distribution. It seems likely therefore that the HLA-DR4 antigen itself rather than a linked susceptibility gene predisposes to RA. In 2 of 3 HLA-DR4 negative families, there were members with autoimmune thyroid disease. It is suggested that genetic susceptibility to RA may be associated with both HLA-DR4 and genes for autoimmune thyroid disease.
在13个经过挑选的多病例家庭中研究了HLA单倍型与类风湿性关节炎（RA）的分离情况。77%的RA先证者存在HLA - DR4（32%为对照）。不同家庭中没有单一的单倍型与RA相关。对受累亲属中HLA单倍型共享情况的分析显示，与预期分布没有显著差异。因此，似乎是HLA - DR4抗原本身而非一个连锁的易感基因使个体易患RA。在3个HLA - DR4阴性家庭中的2个，有自身免疫性甲状腺疾病患者。提示对RA的遗传易感性可能与HLA - DR4以及自身免疫性甲状腺疾病的基因都有关。
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