Luo H Z, Cheng S J, Jang Y Z, Han N J, Li X Q, Yie S Y, Liang J L
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1987 Sep;9(5):328-32.
Possible antimutation of 108 preparations of 91 kinds of vegetables and fruits on Salmonella typhimurium TA98 and TA100 mutants was tested. 4-nitroquinoline-N-oxide (4 NQO), N-methyl-N-nitro-N-nitrosoguanidine (MNNG), aflatoxin B1 (AFB1) and benzo (a) pyrene (BaP) were used as mutagens. The results showed that 67 (62%) preparations had antimutagenic action in vitro to different degrees. 9.6% of all preparations showed inhibition action on 4 NQO in TA100 mutant and 12.3%, in TA98, 5% on MNNG in TA100, 38% on AFB1 in TA100 and 45.1% in TA98, 28.9% on BaP in TA100. This experiment provides a scientific basis to the study of food resources as prevention of carcinogenesis.
检测了91种蔬菜水果的108份制剂对鼠伤寒沙门氏菌TA98和TA100突变体的可能抗突变作用。使用4-硝基喹啉-N-氧化物（4-NQO）、N-甲基-N-硝基-N-亚硝基胍（MNNG）、黄曲霉毒素B1（AFB1）和苯并(a)芘（BaP）作为诱变剂。结果表明，67份（62%）制剂在体外有不同程度的抗诱变作用。所有制剂中9.6%对TA100突变体中的4-NQO有抑制作用，对TA98中的4-NQO抑制作用为12.3%；对TA100中MNNG的抑制作用为5%，对TA100中AFB1的抑制作用为38%，对TA98中AFB1的抑制作用为45.1%；对TA100中BaP的抑制作用为28.9%。该实验为研究作为预防癌症发生的食物资源提供了科学依据。
