Story Pharmaceutics Pty Ltd, PO Box 6086, Linden Park, South Australia, 5065, Australia.
Biochimie. 2021 Feb;181:100-122. doi: 10.1016/j.biochi.2020.11.019. Epub 2020 Dec 9.
Zinc, ω-3 polyunsaturated fatty acids (PUFAs) and vitamin D are essential nutrients for health, maturation and general wellbeing. Extensive literature searches have revealed the widespread similarity in molecular biological properties of zinc, ω-3 PUFAs and vitamin D, and their similar anti-cancer properties, even though they have different modes of action. These three nutrients are separately essential for good health, especially in the aged. Zinc, ω-3 PUFAs and vitamin D are inexpensive and safe as they are fundamentally natural and have the properties of correcting and inhibiting undesirable actions without disturbing the normal functions of cells or their extracellular environment. This review of the anticancer properties of zinc, ω-3 PUFAs and vitamin D is made in the context of the hallmarks of cancer. The anticancer properties of zinc, ω-3 PUFAs and vitamin D can therefore be used beneficially through combined treatment or supplementation. It is proposed that sufficiency of zinc, ω-3 PUFAs and vitamin D is a necessary requirement during chemotherapy treatment and that clinical trials can have questionable integrity if this sufficiency is not checked and maintained during efficacy trials.
锌、ω-3 多不饱和脂肪酸 (PUFA) 和维生素 D 是健康、成熟和整体健康所必需的营养物质。广泛的文献检索揭示了锌、ω-3 PUFAs 和维生素 D 在分子生物学特性上的广泛相似性，以及它们相似的抗癌特性，尽管它们的作用方式不同。这三种营养素对于身体健康都是必不可少的，尤其是在老年人中。锌、ω-3 PUFAs 和维生素 D 价格低廉且安全，因为它们本质上是天然的，具有纠正和抑制不良作用的特性，而不会干扰细胞或其细胞外环境的正常功能。在癌症的标志性特征背景下，对锌、ω-3 PUFAs 和维生素 D 的抗癌特性进行了综述。因此，通过联合治疗或补充，可以有益地利用锌、ω-3 PUFAs 和维生素 D 的抗癌特性。有人提出，在化疗治疗期间，锌、ω-3 PUFAs 和维生素 D 的充足性是必要的要求，如果在疗效试验期间不检查和维持这种充足性，临床试验的完整性可能会受到质疑。
