Story Pharmaceutics Pty Ltd, PO Box 6086, Linden Park, South Australia, 5065, Australia.
Biochimie. 2021 Aug;187:94-109. doi: 10.1016/j.biochi.2021.05.013. Epub 2021 May 31.
Despite the development of a number of vaccines for COVID-19, there remains a need for prevention and treatment of the virus SARS-CoV-2 and the ensuing disease COVID-19. This report discusses the key elements of SARS-CoV-2 and COVID-19 that can be readily treated: viral entry, the immune system and inflammation, and the cytokine storm. It is shown that the essential nutrients zinc, ω-3 polyunsaturated fatty acids (PUFAs), vitamin D and magnesium provide the ideal combination for prevention and treatment of COVID-19: prevention of SARS-CoV-2 entry to host cells, prevention of proliferation of SARS-CoV-2, inhibition of excessive inflammation, improved control of the regulation of the immune system, inhibition of the cytokine storm, and reduction in the effects of acute respiratory distress syndrome (ARDS) and associated non-communicable diseases. It is emphasized that the non-communicable diseases associated with COVID-19 are inherently more prevalent in the elderly than the young, and that the maintenance of sufficiency of zinc, ω-3 PUFAs, vitamin D and magnesium is essential for the elderly to prevent the occurrence of non-communicable diseases such as diabetes, cardiovascular diseases, lung diseases and cancer. Annual checking of levels of these essential nutrients is recommended for those over 65 years of age, together with appropriate adjustments in their intake, with these services and supplies being at government cost. The cost:benefit ratio would be huge as the cost of the nutrients and the testing of their levels would be very small compared with the cost savings of specialists and hospitalization.
尽管已经开发出了多种针对 COVID-19 的疫苗,但仍然需要预防和治疗 SARS-CoV-2 病毒和由此引发的 COVID-19 疾病。本报告讨论了 SARS-CoV-2 和 COVID-19 中易于治疗的关键要素:病毒进入、免疫系统和炎症以及细胞因子风暴。结果表明,锌、ω-3 多不饱和脂肪酸(PUFAs)、维生素 D 和镁等必需营养素为 COVID-19 的预防和治疗提供了理想的组合:预防 SARS-CoV-2 进入宿主细胞,预防 SARS-CoV-2 的增殖,抑制过度炎症,改善免疫系统的调节控制,抑制细胞因子风暴,减少急性呼吸窘迫综合征(ARDS)和相关非传染性疾病的影响。需要强调的是,与 COVID-19 相关的非传染性疾病在老年人中比年轻人更为普遍,因此,老年人维持锌、ω-3 PUFAs、维生素 D 和镁的充足水平对于预防糖尿病、心血管疾病、肺部疾病和癌症等非传染性疾病至关重要。建议对 65 岁以上人群进行这些必需营养素水平的年度检查,并适当调整其摄入量,这些服务和供应由政府承担费用。其成本效益比将非常巨大,因为与专家治疗和住院费用相比,营养素的成本和检测费用非常低。