甲状腺疾病中的病理和免疫因素。
Pathologic and immune factors in thyroid disease.
作者信息
Buckingham B A, Costin G, Kogut M D, Isaacs H, Landing B H
出版信息
J Pediatr. 1977 Nov;91(5):728-33. doi: 10.1016/s0022-3476(77)81024-x.
Thyroid glands from 33 children with hyperthyroidism and nine with juvenile lymphocytic thyroiditis were examined histologically and for IgG, IgA, IgM, and C3 by immunofluorescent staining. There was no significant difference between glands with JLT and those with hyperthyroidism in the degree of lymphoid infiltration or lymphoid follicle formation. In thyroiditis there was no correlation between the degree of histologic abnormalities and the presence of immunofluorescent staining for IgG, IgM, or IgA. In hyperthyroidism there was a correlation between the degree of histologic abnormalities and the presence of IgG. In both groups of patients LI and LFF were distinctly more severe in glands positive for C3. Postsurgical hypothyroidism correlated with LI but not with LFF, IgG, or C3.
对33例甲状腺功能亢进症患儿和9例青少年淋巴细胞性甲状腺炎患儿的甲状腺进行了组织学检查，并通过免疫荧光染色检测了IgG、IgA、IgM和C3。青少年淋巴细胞性甲状腺炎患儿的甲状腺与甲状腺功能亢进症患儿的甲状腺在淋巴细胞浸润程度或淋巴滤泡形成方面无显著差异。在甲状腺炎中，组织学异常程度与IgG、IgM或IgA免疫荧光染色的存在之间无相关性。在甲状腺功能亢进症中，组织学异常程度与IgG的存在之间存在相关性。在两组患者中，C3阳性的甲状腺中淋巴细胞浸润和淋巴滤泡形成明显更严重。术后甲状腺功能减退与淋巴细胞浸润相关，但与淋巴滤泡形成、IgG或C3无关。
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