Intensive Care Unit, Zhongshan People's Hospital, Zhongshan City, Guangdong, China.
Department of Cardiology, Huizhou Municipal Central People's Hospital, Huizhou City, Guangdong, China.
Angiology. 2021 Apr;72(4):371-380. doi: 10.1177/0003319720979238. Epub 2020 Dec 14.
Genome-wide association studies have shown that a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS-9) is associated with the development of atherosclerosis. We assessed the level of ADAMTS-9 in patients with coronary artery disease (CAD) and its severity and prognosis. We selected 666 participants who underwent coronary angiography in our hospital and met the inclusion and exclusion criteria; participants included non-CAD patients, patients with stable angina pectoris (SAP), unstable angina, non-ST-segment elevation myocardial infarction, or ST-segment elevation myocardial infarction. The serum level of ADAMTS-9 was higher in patients with CAD than in non-CAD patients (37.53 ± 8.55 ng/mL vs 12.04 ± 7.02 ng/mL, < .001) and was an independent predictor for CAD (odds ratio = 1.871, 95% CI: 1.533-2.283, < .001). Subgroup analysis showed that compared with the SAP group, the acute coronary syndrome groups had higher serum levels of ADAMTS-9. In addition, the level of ADAMTS-9 was related to the SYNTAX score (r = 0.523, < .001). Patients with acute myocardial infarction (AMI) with elevated levels of ADAMTS-9 had a higher risk of major adverse cardiovascular events (MACE) within 12 months than those with lower levels (log-rank = 4.490, = .034). Plasma ADAMTS-9 levels may be useful for the diagnosis of CAD and as predictors of MACE in AMI patients.
全基因组关联研究表明，解整合素金属蛋白酶 9（ADAMTS-9）与动脉粥样硬化的发展有关。我们评估了冠心病（CAD）患者 ADAMTS-9 的水平及其严重程度和预后。我们选择了 666 名在我院接受冠状动脉造影且符合纳入和排除标准的患者；参与者包括非 CAD 患者、稳定型心绞痛（SAP）患者、不稳定型心绞痛、非 ST 段抬高型心肌梗死或 ST 段抬高型心肌梗死患者。CAD 患者的 ADAMTS-9 血清水平高于非 CAD 患者（37.53±8.55ng/ml 比 12.04±7.02ng/ml， <.001），是 CAD 的独立预测因子（比值比=1.871，95%CI：1.533-2.283， <.001）。亚组分析显示，与 SAP 组相比，急性冠状动脉综合征组的 ADAMTS-9 血清水平更高。此外，ADAMTS-9 水平与 SYNTAX 评分相关（r=0.523， <.001）。ADAMTS-9 水平升高的急性心肌梗死（AMI）患者在 12 个月内发生主要不良心血管事件（MACE）的风险高于水平较低的患者（对数秩检验=4.490， =.034）。血浆 ADAMTS-9 水平可能有助于 CAD 的诊断，并可作为 AMI 患者 MACE 的预测因子。
