Wojciechowska Małgorzata, Nizio Michał, Wróbel Katarzyna, Momot Karol, Czarzasta Katarzyna, Flis Krzysztof, Zarębiński Maciej
Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland.
Department of Invasive Cardiology, Independent Public Specialist Western Hospital John Paul II, Lazarski University, 05-825 Grodzisk Mazowiecki, Poland.
Int J Mol Sci. 2025 Jan 10;26(2):537. doi: 10.3390/ijms26020537.
Despite significant advances in imaging modalities for diagnosing coronary artery disease (CAD), there remains a need for novel diagnostic approaches with high predictive values and fewer limitations. Circulating biomarkers, including cytokines such as interleukin-6 (IL-6) and interleukin-8 (IL-8), cell adhesion molecules such as soluble vascular cell adhesion molecule-1 (sVCAM-1), peptides secreted by endothelial cells such as endothelin-1 (ET-1), and enzymes involved in extracellular matrix remodeling such as a disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS-1) offer a promising alternative. This study aimed to evaluate the correlation between the plasma levels of selected biomarkers and the presence and severity of CAD. We enrolled 40 patients admitted for elective coronary angiography. CAD was defined as having at least one coronary artery stenosis ≥ 50%. The severity of CAD was assessed using the Gensini Score (GS). IL-8 levels were significantly higher in the CAD group, with a mean of 9.78 (SD 0.46) compared to 8.37 (SD 0.40) in the non-CAD group ( = 0.0228). No significant differences were observed for the other biomarkers between the groups. A positive Spearman correlation was found between IL-8 levels and the GS (ρ = 0.39, = 0.017). These findings suggest that IL-8 may have potential as an additional tool for diagnosing or excluding atherosclerosis. Further studies with larger sample sizes are needed to validate its clinical utility.
尽管在诊断冠状动脉疾病（CAD）的成像方式方面取得了重大进展，但仍需要具有高预测价值且局限性较少的新型诊断方法。循环生物标志物，包括细胞因子如白细胞介素-6（IL-6）和白细胞介素-8（IL-8）、细胞粘附分子如可溶性血管细胞粘附分子-1（sVCAM-1）、内皮细胞分泌的肽如内皮素-1（ET-1）以及参与细胞外基质重塑的酶如含血小板反应蛋白基序的解整合素和金属蛋白酶-1（ADAMTS-1）提供了一种有前景的替代方法。本研究旨在评估所选生物标志物的血浆水平与CAD的存在及严重程度之间的相关性。我们纳入了40例因择期冠状动脉造影而入院的患者。CAD被定义为至少有一支冠状动脉狭窄≥50%。使用Gensini评分（GS）评估CAD的严重程度。CAD组的IL-8水平显著更高，均值为9.78（标准差0.46），而非CAD组为8.37（标准差0.40）（P = 0.0228）。两组之间其他生物标志物未观察到显著差异。IL-8水平与GS之间存在正Spearman相关性（ρ = 0.39，P = 0.017）。这些发现表明，IL-8可能有潜力作为诊断或排除动脉粥样硬化的额外工具。需要更大样本量的进一步研究来验证其临床实用性。
