Department of Gastroenterology, Yiwu Central Hospital, the Affiliated Yiwu Hospital of 26453Wenzhou Medical University, Zhejiang, China.
Department of Respiratory and Critical Medicine, the Fourth Affiliated Hospital, 12377Zhejiang University, Zhejiang, China.
Int J Toxicol. 2021 Mar-Apr;40(2):171-177. doi: 10.1177/1091581820972311. Epub 2020 Dec 14.
Increasing evidence indicates that environmental pollutants can change human gut microbiota. Microcystin-leucine arginine (MC-LR), considered a major hazard to mammals, is one of the important contaminants. However, little is known about the long-term influence of MC-LR on gut microbial communities. We aimed to investigate the effect of MC-LR on gut microbiota composition and functions by conducting a chronic exposure of male mice to MC-LR via the oral route. Using 16S rRNA gene sequencing analysis on cecum samples of mice, our results showed that significant changes of species diversity were observed in the gut microbiota of MC-LR-exposed mice. In addition, comparative analysis of the microbial communities showed that the reduction of the and populations was detected in MC-LR-exposed mice. Collectively, our study highlighted the significant effects of MC-LR on the shift of gut microbial communities which could contribute to the development of metabolic syndromes.
越来越多的证据表明，环境污染物会改变人类肠道微生物群。微囊藻毒素-亮氨酸-精氨酸（MC-LR）被认为是对哺乳动物的主要危害之一，是重要的污染物之一。然而，人们对 MC-LR 对肠道微生物群落的长期影响知之甚少。我们旨在通过经口途径给雄性小鼠进行慢性 MC-LR 暴露，研究 MC-LR 对肠道微生物群落组成和功能的影响。我们使用 16S rRNA 基因测序分析小鼠盲肠样本，结果表明，MC-LR 暴露组小鼠的肠道微生物多样性发生了显著变化。此外，微生物群落的比较分析表明，MC-LR 暴露组小鼠中 和 种群减少。总之，我们的研究强调了 MC-LR 对肠道微生物群落转移的显著影响，这可能有助于代谢综合征的发展。
