Scopp I W, Fletcher P D, Wyman B S, Epstein S R, Fine A
J Periodontol. 1977 Aug;48(8):484-6. doi: 10.1902/jop.1977.48.8.484.
Twenty consecutive hospital patients who were to have periodontal surgery were assigned to one of two groups in a double blind clinical study. Ten were placed on tetracycline 250 mg, 6 times per day for 5 days. The other ten were given an identical appearing placebo 6 times per day for 5 days. The capsules were placed in a brown envelope so that neither the patient nor the periodontist knew which medication was being administered. The patients were randomly assigned to one of the two groups and were evaluated subjectively and objectively on the 3rd day and the 7th day. Statistically there were no differences between the two groups. In both groups there was some inflammation on the 3rd day but on the 7th day, it had subsided. Tetracycline is not recommended for routine prophylactic use in periodontal surgery.
在一项双盲临床研究中，20名即将接受牙周手术的连续住院患者被分为两组。其中10人服用250毫克四环素，每天6次，共5天。另外10人则每天服用6次外观相同的安慰剂，共5天。胶囊被装在一个棕色信封里，这样患者和牙周病医生都不知道服用的是哪种药物。患者被随机分配到两组中的一组，并在第3天和第7天进行主观和客观评估。统计学上两组之间没有差异。两组在第3天都有一些炎症，但在第7天时炎症已经消退。不建议在牙周手术中常规预防性使用四环素。
