Department of Urology, Ghent University Hospital, Belgium; Faculty of Medicine and Health Science, Department of Human Structure and Repair, Ghent University, Belgium.
Faculty of Medicine and Health Science, Department of Human Structure and Repair, Ghent University, Belgium.
Maturitas. 2021 Jan;143:41-46. doi: 10.1016/j.maturitas.2020.08.008. Epub 2020 Aug 22.
Limited literature concerning nocturia in early postmenopausal women is available. However, due to the lack of endogenous estrogen in these women, an increased prevalence of nocturia is expected.
This prospective observational trial recruited 210 'early' postmenopausal women consulting the Ghent University menopause clinic. Postmenopausal status was biochemically confirmed. Women completed 3 questionnaires: the ICI questionnaire on nocturia (ICIQ-N); 'Targeting the individual's Aetiology of Nocturia to Guide Outcomes' (TANGO) and the Perceived Stress Scale (PSS). Moreover, information concerning women's age, anthropometrics and lifestyle was collected. Nocturia was defined as two or more nocturnal voids.
Nocturia was reported in 24.8% (52/210) of the postmenopausal women. Bother increased with every nocturnal void. Women with two or more nighttime voids were found to have significantly increased prevalence of urgency compared with women with only one (p < 0.001; 38.5% versus 22.7%). Trouble initiating sleep at the start of the night and insomnia during the night were significantly different in women with a different nocturnal frequency (initiating sleep p = 0.09, no voids 34.4 %, 1 void 39.2 %, ≥ 2 voids 53.8 %; insomnia p < 0.001; no voids 1.6%, 1 void 22.7 %, ≥ 2 voids 53.8 %). In addition to bladder and sleep dysfunctions, waist circumference was a risk factor for nocturia (OR 1.04; 95 % CI: 1.01-1.08).
Nocturia is an important problem in early postmenopausal women, affecting a quarter of the questioned women. Etiology of nocturia in this population is multifactorial as estrogen withdrawal is accompanied by bladder and sleep dysfunctions.
有关绝经后早期妇女夜尿症的文献有限。然而，由于这些女性缺乏内源性雌激素，预计夜尿症的患病率会增加。
这项前瞻性观察性试验招募了 210 名咨询根特大学更年期诊所的“早期”绝经后女性。绝经后状态通过生化确认。女性完成了 3 份问卷：国际尿控协会（ICIQ）夜尿症问卷（ICIQ-N）；“针对个体夜尿症病因以指导结果”（TANGO）和感知压力量表（PSS）。此外，还收集了有关女性年龄、人体测量和生活方式的信息。夜尿症定义为两次或更多次夜间排尿。
210 名绝经后女性中，有 24.8%（52/210）报告有夜尿症。每增加一次夜间排尿，困扰就会增加。与仅有一次夜间排尿的女性相比，有两次或更多次夜间排尿的女性出现尿急的患病率显著增加（p<0.001；38.5%对 22.7%）。在夜间开始时入睡困难和夜间失眠在夜间排尿频率不同的女性中存在显著差异（入睡困难 p=0.09，无排尿 34.4%，1 次排尿 39.2%，≥2 次排尿 53.8%；失眠 p<0.001；无排尿 1.6%，1 次排尿 22.7%，≥2 次排尿 53.8%）。除了膀胱和睡眠功能障碍外，腰围也是夜尿症的一个危险因素（OR 1.04；95%CI：1.01-1.08）。
夜尿症是绝经后早期妇女的一个重要问题，影响了四分之一接受调查的女性。该人群夜尿症的病因是多因素的，因为雌激素缺乏伴随着膀胱和睡眠功能障碍。
