Department of Urology, National Taiwan University Hospital and College of Medicine, No. 7, Chung Shan South Road, Taipei, 10002, Taiwan.
Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
World J Urol. 2018 Nov;36(11):1853-1862. doi: 10.1007/s00345-018-2329-0. Epub 2018 May 23.
To examine the prevalence, symptomatology, and risk factors for nocturia using data from an internet-based questionnaire conducted in China, South Korea, and Taiwan.
Data from a cross-sectional, population-representative, internet-based study conducted among men and women aged ≥ 40 years were analysed post hoc. Nocturia prevalence and bother were analysed by sex and age group, and with regard to comorbid conditions and lower urinary tract symptoms (LUTS). Multivariate and univariate logistic regression models to identify risk factors for nocturia were constructed, with nocturia involving ≥ 2 nocturnal voids as the dependent variable.
Among the 8284 participants, the prevalence of nocturia involving ≥ 1, ≥ 2, or ≥ 3 voids was slightly higher for women (76.1, 37.3, and 17.5%, respectively) compared with men (74.0, 34.5, and 15.5%, respectively). The prevalence and associated bother of nocturia increased with age. Greater proportions of patients with comorbid conditions or wet/more severe overactive bladder syndrome (OAB) experienced nocturia than those without. Multivariate analysis identified that female sex, age > 60 years, diabetes, cardiac disease, body mass index, International Prostate Symptom Score (IPSS) voiding score, stress urinary incontinence, wet OAB, and Hospital Anxiety And Depression Scale (HADS) anxiety score were associated with ≥ 2 nocturnal voids. Hypertension was associated with ≥ 2 nocturnal voids in women but not men, and alcohol consumption in men but not women.
Nocturia is a common and bothersome condition affecting a large proportion of men and women aged ≥ 40 years in China, South Korea, and Taiwan. Factors associated with nocturia included age, sex, comorbid conditions, and LUTS.
This study is registered at ClinicalTrials.gov: NCT02618421.
利用来自中国、韩国和中国台湾互联网问卷调查的数据，研究夜尿症的流行情况、症状和危险因素。
对一项针对年龄≥40 岁的男性和女性进行的横断面、人群代表性、基于互联网的研究数据进行了事后分析。按性别和年龄组分析夜尿症的流行情况和困扰程度，并分析合并症和下尿路症状（LUTS）。构建了多变量和单变量逻辑回归模型，以确定夜尿症的危险因素，将涉及≥2 次夜间排尿的夜尿症作为因变量。
在 8284 名参与者中，女性夜尿症发生率（涉及≥1、≥2 或≥3 次夜间排尿的发生率分别为 76.1%、37.3%和 17.5%）略高于男性（74.0%、34.5%和 15.5%）。夜尿症的患病率及其相关困扰随年龄增长而增加。患有合并症或湿/更严重的膀胱过度活动症（OAB）的患者比无合并症的患者经历夜尿症的比例更高。多变量分析发现，女性、年龄>60 岁、糖尿病、心脏病、体重指数、国际前列腺症状评分（IPSS）排尿评分、压力性尿失禁、湿 OAB 和医院焦虑抑郁量表（HADS）焦虑评分与≥2 次夜间排尿有关。高血压与女性但与男性无关，而饮酒与男性但与女性无关。
夜尿症是一种常见且令人困扰的疾病，影响了中国、韩国和中国台湾地区年龄≥40 岁的大量男性和女性。与夜尿症相关的因素包括年龄、性别、合并症和 LUTS。
本研究在 ClinicalTrials.gov 注册：NCT02618421。
