Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK.
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil; Centro Nacional de Biologia Estrutural e Bioimagem (CENABIO), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Trends Parasitol. 2021 Apr;37(4):317-329. doi: 10.1016/j.pt.2020.11.005. Epub 2020 Dec 8.
The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. are flagellate eukaryotic parasites that cause serious diseases in humans and animals. These parasites have cell shapes defined by a subpellicular microtubule array and all share a number of important cellular features. One of these is the flagellar pocket, an invagination of the cell membrane around the proximal end of the flagellum, which is an important organelle for endo/exocytosis. The flagellar pocket plays a crucial role in parasite pathogenicity and persistence in the host and has a great influence on cell morphogenesis and cell division. Here, we compare the morphology and function of the flagellar pockets between different trypanosomatids, with their life cycles and ecological niches likely influencing these differences.
锥虫门中的布氏锥虫、克氏锥虫和利什曼原虫等都是鞭毛原生动物真核寄生虫，会导致人和动物罹患严重疾病。这些寄生虫的细胞形状由亚膜微管阵列定义，它们都具有一些重要的细胞特征。其中之一是鞭毛口袋，这是鞭毛近端周围细胞膜的内陷，是内吞/外排的重要细胞器。鞭毛口袋在寄生虫的致病性和在宿主中的持久性方面起着关键作用，并且对细胞形态发生和细胞分裂有很大影响。在这里，我们比较了不同锥虫之间的鞭毛口袋的形态和功能，它们的生命周期和生态位可能会影响这些差异。
