不只是微管：动基体类生物的亚膜微管束的结构与功能。
More than Microtubules: The Structure and Function of the Subpellicular Array in Trypanosomatids.
机构信息
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.
出版信息
Trends Parasitol. 2019 Oct;35(10):760-777. doi: 10.1016/j.pt.2019.07.008. Epub 2019 Aug 27.
The subpellicular microtubule array defines the wide range of cellular morphologies found in parasitic kinetoplastids (trypanosomatids). Morphological studies have characterized array organization, but little progress has been made towards identifying the molecular mechanisms that are responsible for array differentiation during the trypanosomatid life cycle, or the apparent stability and longevity of array microtubules. In this review, we outline what is known about the structure and biogenesis of the array, with emphasis on Trypanosoma brucei, Trypanosoma cruzi, and Leishmania, which cause life-threatening diseases in humans and livestock. We highlight unanswered questions about this remarkable cellular structure that merit new consideration in light of our recently improved understanding of how the 'tubulin code' influences microtubule dynamics to generate complex cellular structures.
叶状体下微管阵列定义了广泛的寄生动基体（原生动物）中发现的细胞形态。形态学研究已经对微管阵列的组织进行了特征描述，但在鉴定负责动基体生命周期中微管阵列分化的分子机制，或微管阵列的明显稳定性和长寿性方面，进展甚微。在这篇综述中，我们概述了已知的微管阵列的结构和生物发生，重点介绍了引起人类和家畜致命疾病的布氏锥虫、克氏锥虫和利什曼原虫。我们强调了关于这个显著的细胞结构的一些尚未解决的问题，这些问题值得我们在考虑“微管蛋白代码”如何影响微管动力学以产生复杂的细胞结构方面的最新理解的基础上，重新进行考虑。
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