戊萜类化合物A - C，从小麦孢囊线虫的产黄青霉中分离得到的新型倍半萜代谢产物。
Peniterpenoids A-C, new sesquiterpenoid metabolites from a wheat cyst nematode Penicillium janthinellum.
作者信息
Liu Sushi, Fan Wenwen, Ren Jinwei, Wang Wenzhao, Liu Xingzhong, Liang Yonghong, Wei Tao, Li Erwei
机构信息
Beijing Key Laboratory of Bioactive Substance and Functional Foods, Beijing Union University, Beijing 100191, China; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
出版信息
Fitoterapia. 2021 Jan;148:104801. doi: 10.1016/j.fitote.2020.104801. Epub 2020 Dec 10.
Three new sesquiterpenoids, peniterpenoids A - C (1-3), together with six known metabolites (4-9) were isolated from an entomogenous fungus Penicillium janthinellum (LB1.20090001) collected from a wheat cyst nematode. The structures of the new compounds were elucidated based on NMR and HRESIMS spectroscopic analyses. The absolute configuration of the C-8 secondary alcohol of peniterpenoid B (2) was determined by [Rh(OCOCF)]-induced ECD experiment. Subsequently, the antimicrobial and DPPH scavenging activities were determined. Compounds 6-8 exhibited moderate antibacterial activities against Staphylococcus aureus (CGMCC1.2465) with MIC values of 25.0, 50.0 and 12.5 μg/mL, respectively.
从采自小麦粒线虫的昆虫病原真菌展青霉（LB1.20090001）中分离得到了3个新的倍半萜类化合物，即青霉萜类化合物A - C（1 - 3），以及6个已知代谢产物（4 - 9）。基于核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）光谱分析阐明了这些新化合物的结构。通过[Rh(OCOCF)]诱导的电子圆二色（ECD）实验确定了青霉萜类化合物B（2）中C - 8仲醇的绝对构型。随后，测定了其抗菌和清除1,1 - 二苯基 - 2 - 三硝基苯肼（DPPH）的活性。化合物6 - 8对金黄色葡萄球菌（CGMCC1.2465）表现出中等抗菌活性，其最低抑菌浓度（MIC）值分别为25.0、50.0和12.5μg/mL。
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