阿魏中具有抗多重耐药金黄色葡萄球菌活性的倍半萜类化合物。
Sesquiterpenoids with Anti-MDR Staphylococcus aureus activities from Ferula ferulioides.
作者信息
Liu Tao, Wang Shuangying, Xu Lili, Fu Wei, Gibbons Simon, Mu Qing
机构信息
School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Pudong, Shanghai 201203, P. R. China (phone: +86-21-51980109).
出版信息
Chem Biodivers. 2015 Apr;12(4):599-614. doi: 10.1002/cbdv.201400150.
Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides (Steud.) Korovin. Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration (MIC) values in the range of 0.5-128 mg/l.
从药用植物阿魏（Ferula ferulioides (Steud.) Korovin）中分离出7个新的倍半萜类化合物以及21个已知的倍半萜类衍生物。通过全面的光谱分析和化学转化对它们的结构进行了阐明。对分离得到的化合物针对包括多重耐药菌（MDR）和耐甲氧西林金黄色葡萄球菌（MRSA）在内的一组细菌进行了抗菌活性评估，其最低抑菌浓度（MIC）值在0.5 - 128mg/L范围内。
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