Yan Shu-Ting, Gao Feng, Dong Tai-Wei, Fan Hao, Xi Miao-Miao, Miao Feng, Wei Pei-Feng
College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Road, Qindu District, Xianyang, Shaanxi 712046, China.
The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Weiyang West Road, Qindu District, Xianyang, Shaanxi 712046, China.
Evid Based Complement Alternat Med. 2020 Nov 27;2020:8877791. doi: 10.1155/2020/8877791. eCollection 2020.
To systematically evaluate the clinical efficacy of Xueshuantong injection ( saponins) in preventing deep venous thrombosis (DVT) of lower extremity after orthopedic surgery.
The randomized controlled trials (RCTs) of Xueshuantong injection in prevention of lower extremity DVT after orthopedic surgery were retrieved from CNKI, Wanfang database, VIP, PubMed, and Cochrane Library by August 2020. Revman5.2 was used to analyze the results.
A total of 20 articles including 2336 patients were included. The results of meta-analysis showed that the incidence of DVT in the experimental group was lower than that in the control group; after operation, the D-dimer (Ddimer), thrombin time (APTT), and prothrombin time (PT) in the experimental group were significantly improved compared with those in the control group, and the difference between the two groups was statistically significant.
Xueshuantong injection can effectively prevent the formation of lower extremity DVT after orthopedic surgery and antagonize the postoperative hypercoagulable state of blood, which has high clinical value.
系统评价血栓通注射液（皂苷）预防骨科手术后下肢深静脉血栓形成（DVT）的临床疗效。
通过检索中国知网、万方数据库、维普数据库、PubMed及考克兰图书馆，收集截至2020年8月关于血栓通注射液预防骨科手术后下肢DVT的随机对照试验（RCT）。采用Revman5.2软件进行结果分析。
共纳入20篇文章，涉及2336例患者。Meta分析结果显示，试验组DVT发生率低于对照组；术后试验组D-二聚体（Ddimer）、活化部分凝血活酶时间（APTT）及凝血酶原时间（PT）较对照组明显改善，两组差异有统计学意义。
血栓通注射液能有效预防骨科手术后下肢DVT形成，拮抗术后血液高凝状态，具有较高的临床应用价值。
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