Linda Dalessio is Associate Professor of Nursing, Western Connecticut State University, 181 White Street, Danbury, CT 06810 (
AACN Adv Crit Care. 2020 Dec 15;31(4):383-393. doi: 10.4037/aacnacc2020535.
More than 356 000 out-of-hospital cardiac arrests occur in the United States annually. Complications involving post-cardiac arrest syndrome occur because of ischemic-reperfusion injury to the brain, lungs, heart, and kidneys. Post-cardiac arrest syndrome is a clinical state that involves global brain injury, myocardial dysfunction, macrocirculatory dysfunction, increased vulnerability to infection, and persistent precipitating pathology (ie, the cause of the arrest). The severity of outcomes varies and depends on precipitating factors, patient health before cardiac arrest, duration of time to return of spontaneous circulation, and underlying comorbidities. In this article, the pathophysiology and treatment of post-cardiac arrest syndrome are reviewed and potential novel therapies are described.
每年在美国有超过 356000 例院外心脏骤停事件发生。由于脑、肺、心脏和肾脏的缺血再灌注损伤，会出现涉及心搏骤停后综合征的并发症。心搏骤停后综合征是一种涉及全脑损伤、心肌功能障碍、大循环功能障碍、易感染增加和持续诱发病理（即，骤停的原因）的临床状态。其结果的严重程度各不相同，取决于诱发因素、心脏骤停前患者的健康状况、自主循环恢复时间的长短以及潜在的合并症。本文回顾了心搏骤停后综合征的病理生理学和治疗方法，并描述了潜在的新疗法。
