Division of Laboratory and Genomic Medicine, Department of Pathology, University of California San Diego Health System, La Jolla, California, USA.
Department of Dermatology, University of California San Diego Health System, La Jolla, California, USA.
J Cutan Pathol. 2021 May;48(5):659-662. doi: 10.1111/cup.13936. Epub 2020 Dec 22.
Primary cutaneous anaplastic large-cell lymphoma and breast implant-associated ALCL (BIA-ALCL) are rare subtypes of anaplastic lymphoma kinase (ALK)-negative ALCLs originating from skin and breast implants, respectively. Herein, we report a unique case of cutaneous ALK-negative ALCL occurring in the skin of left medial breast from a patient with multiple rounds of bilateral breast implants and a history of breast carcinoma. The lymphoma cells are entirely confined to the lymphatic channels in the dermis, and the patient has no other areas of skin abnormality, no lymphadenopathy, peri-implant fluid accumulation, or masses from the bilateral capsules of implants. The differential diagnosis and its relationship with breast implants are further explored.
原发性皮肤间变大细胞淋巴瘤和乳房植入物相关间变大细胞淋巴瘤（BIA-ALCL）分别是源自皮肤和乳房植入物的罕见的间变性淋巴瘤激酶（ALK）阴性间变大细胞淋巴瘤亚型。本文报道了一例独特的病例，患者曾多次接受双侧乳房植入物治疗且患有乳腺癌，现于左侧乳房内侧皮肤发生 ALK 阴性间变大细胞淋巴瘤。淋巴瘤细胞完全局限于真皮内的淋巴管内，患者无其他皮肤异常、无淋巴结病、植入物周围积液或双侧植入物包膜肿块。进一步探讨了鉴别诊断及其与乳房植入物的关系。
