Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Vic., Australia.
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Vic., Australia.
Australas J Ageing. 2021 Mar;40(1):35-47. doi: 10.1111/ajag.12892. Epub 2020 Dec 13.
To systematically assess the literature examining the association between foot disease (foot ulceration, infection, critical ischaemia and/or Charcot neuroarthropathy) and physical function in older adults.
Literature search of MEDLINE, Embase and CINAHL was performed. Studies were included if foot disease and physical function were assessed in participants of mean or median age ≥ 65 years.
Of 2,574 abstracts screened, 19 studies (13 longitudinal, 6 cross-sectional) reporting on 5634 participants, 43% female, were included. Diabetes-related foot disease and critical ischaemia were most studied (n = 5017, 40% female). In 8 studies with control groups, foot disease was associated with poorer physical function. Meta-analysis of 5 studies (n = 1503, 45% female) found an association between foot disease and poorer physical function (SMD (95% CI): 1.00 (0.40, 1.62), P < 0.001).
Foot disease is associated with poorer physical function in older adults. Future research should include broader study populations and intervention strategies.
系统评估文献中关于足部疾病（足部溃疡、感染、严重缺血和/或夏科氏关节病）与老年人身体功能之间关联的研究。
对 MEDLINE、Embase 和 CINAHL 进行文献检索。如果研究中评估了平均或中位年龄≥65 岁的参与者的足部疾病和身体功能，则将其纳入研究。
在筛选出的 2574 篇摘要中，纳入了 19 项研究（13 项纵向研究，6 项横断面研究），共涉及 5634 名参与者，其中 43%为女性。糖尿病相关的足部疾病和严重缺血性疾病研究最多（n=5017，40%为女性）。在 8 项有对照组的研究中，足部疾病与较差的身体功能相关。对 5 项研究（n=1503，45%为女性）的荟萃分析发现，足部疾病与较差的身体功能之间存在关联（SMD（95%CI）：1.00（0.40，1.62），P<0.001）。
足部疾病与老年人身体功能较差有关。未来的研究应包括更广泛的研究人群和干预策略。
