光生物调节对体外培养的人真皮成纤维细胞的影响：系统评价。
The effects of photobiomodulation on human dermal fibroblasts in vitro: A systematic review.
机构信息
Institute of Health and Sport, Victoria University, Melbourne, Australia; First Year College, Victoria University, Melbourne, Australia; Osteopathy Group, College of Health and Biomedicine, Victoria University, Melbourne, Australia; Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Australia.
Osteopathy Group, College of Health and Biomedicine, Victoria University, Melbourne, Australia.
出版信息
J Photochem Photobiol B. 2021 Jan;214:112100. doi: 10.1016/j.jphotobiol.2020.112100. Epub 2020 Dec 4.
Photobiomodulation (PBM) is reported to impart a range of clinical benefits, from the healing of chronic wounds to athletic performance enhancement. The increasing prevalence of this therapy conflicts with the lack of understanding concerning specific cellular mechanisms induced by PBM. Herein, we systematically explore the literature base, specifically related to PBM (within the range 600-1070 nm) and its influence on dermal fibroblasts. The existing research in this field is appraised through five areas: cellular proliferation and viability; cellular migration; ATP production and mitochondrial membrane potential; cellular protein expression and synthesis; and gene expression. This review demonstrates that when fibroblasts are irradiated in vitro within a set range of intensities, they exhibit a multitude of positive effects related to the wound healing process. However, the development of an optimal in vitro framework is paramount to improve the reliability and validity of research in this field.
光生物调节（PBM）被报道具有多种临床益处，从慢性伤口的愈合到运动表现的提高。这种治疗方法的日益普及与人们对 PBM 诱导的特定细胞机制缺乏了解相冲突。在此，我们系统地研究了文献基础，特别是与 PBM（波长范围为 600-1070nm）及其对真皮成纤维细胞的影响相关的文献。通过五个方面评估该领域的现有研究：细胞增殖和活力；细胞迁移；ATP 产生和线粒体膜电位；细胞蛋白表达和合成；以及基因表达。本综述表明，当成纤维细胞在体外的设定强度范围内受到照射时，它们表现出与伤口愈合过程相关的多种积极影响。然而，开发最佳的体外框架对于提高该领域研究的可靠性和有效性至关重要。
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