Institute of Laboratory Medicine, Unfallkrankenhaus Berlin, 12683 Berlin, Germany.
Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.
Int J Mol Sci. 2020 Dec 9;21(24):9383. doi: 10.3390/ijms21249383.
Coagulation and fibrinolysis are interrelated with the expression of vascular endothelial growth factor (VEGF), which frequently is increased in axial spondyloarthritis (axSpA). We tested whether (i) α-antiplasmin (A2AP) Arg6Trp, (ii) fibrinogen, factor XIII A-subunit or B-subunit genotypes are associated with VEGF levels and assessed whether the known association between elevated VEGF and radiographic spinal progression in axSpA depends on genetic background.
One hundred and eighty-six axSpA patients from the German Spondyloarthritis Inception Cohort were genotyped, characterized for VEGF levels, and statistically analyzed. The association between VEGF and radiographic spinal progression was assessed in dependence on genetic background in stratified analyses.
A2AP 6Trp carriage was associated with VEGF elevation (OR: 2.37, 95% CI: 1.06-5.29) and VEGF levels (6Trp, 455 ± 334 pg/mL; 6Arg/Arg, 373 ± 293 pg/mL; < 0.008). Association between elevated VEGF and radiographic spinal progression in axSpA (OR: 3.11, 95% CI: 1.02-8.82) depended remarkably on the fibrinogen (FGA) genotype. When considering axSpA patients with elevated VEGF, in FGA rs6050A>G wild types, 42.1% of patients (8 of 19) progressed, while in G-allele carriers, no radiographic progression happened (0 of 13) ( < 0.04).
The A2AP Arg6Trp genotype seems to influence VEGF levels in axSpA. The predictive value of VEGF elevations in respect of radiographic spinal progression in axSpA depends on FGA genotypes.
凝血和纤溶与血管内皮生长因子（VEGF）的表达有关，VEGF 在轴性脊柱关节炎（axSpA）中常升高。我们检测了（i）α2-抗纤溶酶（A2AP）Arg6Trp，（ii）纤维蛋白原、因子 XIII A 亚单位或 B 亚单位基因型是否与 VEGF 水平相关，并评估了 axSpA 中已知的升高的 VEGF 与放射学脊柱进展之间的相关性是否依赖于遗传背景。
186 名来自德国脊柱关节炎发病队列的 axSpA 患者进行了基因分型、VEGF 水平检测，并进行了统计学分析。在分层分析中，评估了 VEGF 与放射学脊柱进展之间的相关性是否依赖于遗传背景。
A2AP 6Trp 携带与 VEGF 升高相关（OR：2.37，95%CI：1.06-5.29）和 VEGF 水平（6Trp，455±334 pg/mL；6Arg/Arg，373±293 pg/mL； < 0.008）。axSpA 中升高的 VEGF 与放射学脊柱进展之间的相关性（OR：3.11，95%CI：1.02-8.82）显著依赖于纤维蛋白原（FGA）基因型。在考虑 axSpA 患者中升高的 VEGF 时，在 FGA rs6050A>G 野生型中，42.1%的患者（19 例中有 8 例）进展，而在 G 等位基因携带者中，没有放射学进展（13 例中无 1 例）（ < 0.04）。
A2AP Arg6Trp 基因型似乎影响 axSpA 中的 VEGF 水平。axSpA 中 VEGF 升高对放射学脊柱进展的预测价值取决于 FGA 基因型。
