Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
German Rheumatism Research Centre, Berlin, Germany.
Curr Rheumatol Rep. 2017 Sep;19(9):55. doi: 10.1007/s11926-017-0681-5.
The purpose of this review is to discuss new evidence explaining the progress from bony inflammation over repair tissue to new bone formation in axial spondyloartrhitis and its correlations in imaging and histology of the bone.
Data from imaging, histology and treatment interventions indicates that the disease starts with inflammation, followed by replacement of subchondral bone marrow by repair tissue which presence is crucial for the stimulation of new bone formation. The magnetic resonance imaging (MRI) sequences of STIR and T1 are currently the most commonly used imaging techniques to follow this process; explanations are offered for the limited sensitivity to detect these bony changes on MRI in their different phases. Early and effective anti-inflammatory treatment is crucial for the prevention of long-term ankylosis. Whether there are currently also treatment options targeting new bone formation in these patients directly is less clear.
本文旨在讨论新的证据，以解释强直性脊柱炎中从骨炎症到修复组织再到新骨形成的进展及其在影像学和骨组织学中的相关性。
影像学、组织学和治疗干预的数据表明，该疾病首先是炎症，随后是软骨下骨髓被修复组织取代，修复组织的存在对新骨形成的刺激至关重要。目前，磁共振成像（MRI）的 STIR 和 T1 序列是最常用的影像学技术来跟踪这一过程；对于在不同阶段检测这些骨变化的 MRI 技术的有限敏感性，本文给出了相关解释。早期和有效的抗炎治疗对于预防长期强直至关重要。目前在这些患者中是否存在直接针对新骨形成的治疗方法尚不清楚。
