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患者腹疝修补前后的生活质量。

Patient quality of life before and after ventral hernia repair.

机构信息

Department of Surgery, Lyndon B. Johnson General Hospital, McGovern Medical School at UTHealth, Houston, TX.

Department of Surgery, Lyndon B. Johnson General Hospital, McGovern Medical School at UTHealth, Houston, TX.

出版信息

Surgery. 2021 May;169(5):1158-1163. doi: 10.1016/j.surg.2020.11.003. Epub 2020 Dec 11.

Abstract

BACKGROUND

Recurrence is often reported as the primary outcome among studies of patients with hernias; however, there is growing interest in patient quality of life. The relationship between quality of life and recurrence is poorly understood. This study evaluates this relationship.

METHODS

A secondary analysis of 3 prospective clinical trials was performed. The modified Activities Assessment Scale, a validated, abdominal wall-specific quality of life tool was used (1 = poor quality of life and 100 = perfect quality of life). Patients with and without a hernia recurrence were compared. Baseline quality of life, follow-up quality of life, and change in quality of life were measured. The relationship between quality of life and clinical outcomes was examined.

RESULTS

A total of 238 patients were followed for median (range) 30 (14-44) months, of whom 31 (13.0%) had a clinical recurrence, whereas 207 (87.0%) had no clinical recurrence. Patients with recurrence were more likely to have a lower mean baseline quality of life (14 vs 26; P = .035), follow-up quality of life (42 vs 82; P < .001), and change in quality of life (19 vs 33; P < .018). The majority of patients with or without recurrence still experienced an improvement in quality of life (68% vs 79%; P = .142).

CONCLUSION

Patients with lower baseline quality of life are likely to experience a recurrence following repair; however, most still report substantial improvements in quality of life. Assessing follow-up quality of life without accounting for baseline quality of life is incomplete; follow-up quality of life should be assessed with appropriate adjustment for baseline quality of life.

摘要

背景

在疝患者的研究中,复发通常被报道为主要结局;然而,人们对患者生活质量的兴趣日益增加。生活质量与复发之间的关系尚未得到充分理解。本研究评估了这种关系。

方法

对 3 项前瞻性临床试验进行了二次分析。使用改良活动评估量表(一种经过验证的腹壁特异性生活质量工具)进行评估(1=生活质量差,100=生活质量完美)。比较有和无疝复发的患者。测量基线生活质量、随访生活质量和生活质量变化。检查生活质量与临床结局之间的关系。

结果

共有 238 例患者接受了中位数(范围)为 30(14-44)个月的随访,其中 31 例(13.0%)出现临床复发,而 207 例(87.0%)无临床复发。复发患者的平均基线生活质量(14 分比 26 分;P=.035)、随访生活质量(42 分比 82 分;P<0.001)和生活质量变化(19 分比 33 分;P<.018)更差。有或无复发的患者中,大多数仍经历生活质量的改善(68%比 79%;P=.142)。

结论

基线生活质量较低的患者在修复后更有可能出现复发;然而,大多数患者仍报告生活质量有较大改善。在不考虑基线生活质量的情况下评估随访生活质量是不完整的;应使用适当的基线生活质量调整来评估随访生活质量。

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