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电压门控钾通道边缘叶脑炎表现为功能性认知障碍。

Voltage-gated potassium channel limbic encephalitis presenting as functional cognitive impairment.

机构信息

Psychiatric Liaison Service (Queen's Hospital), NELFT NHS Foundation Trust, Romford, Essex, UK.

Psychiatric Liaison Service (Queen's Hospital), NELFT NHS Foundation Trust, Romford, Essex, UK

出版信息

BMJ Case Rep. 2020 Dec 13;13(12):e233179. doi: 10.1136/bcr-2019-233179.

Abstract

Limbic encephalitis is often reported to present as seizures and impaired cognition with little focus on psychiatric presentations. In this case report, we present a 49-year-old man who initially presented to the Psychiatric Liaison Service with a several month history of confusion with the additional emergence of visual hallucinations and delusions. Due to the inconsistent nature of the symptoms in the context of a major financial stressor, a provisional functional cognitive impairment diagnosis was made. Investigations later revealed a positive titre of voltage-gated potassium channel (VGKC) antibodies, subtype leucine-rich glioma inactivated 1 accounting for his symptoms which dramatically resolved with steroids and immunoglobulins. This case highlighted the need for maintaining broad differential diagnoses in a patient presenting with unusual psychiatric symptoms.

摘要

边缘性脑炎常表现为癫痫发作和认知障碍,而很少出现精神科表现。在本病例报告中,我们介绍了一位 49 岁男性,他最初因精神科联络服务就诊,有几个月的意识混乱病史,并有视觉幻觉和妄想的出现。由于症状在重大经济压力源下的性质不一致,因此暂定为功能性认知障碍的诊断。进一步的检查显示电压门控钾通道 (VGKC) 抗体阳性,亚型富亮氨酸胶质瘤失活 1 型,这解释了他的症状,类固醇和免疫球蛋白治疗后症状显著缓解。这个病例强调了在出现不典型精神症状的患者中需要保持广泛的鉴别诊断。

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本文引用的文献

1
The Psychiatric Phenotype of Anti-NMDA Receptor Encephalitis.
J Neuropsychiatry Clin Neurosci. 2019 Winter;31(1):70-79. doi: 10.1176/appi.neuropsych.17120343. Epub 2018 Oct 31.
2
LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes.
J Neurol Neurosurg Psychiatry. 2018 May;89(5):526-534. doi: 10.1136/jnnp-2017-315720. Epub 2017 Oct 21.
3
Red Flags: Clinical Signs for Identifying Autoimmune Encephalitis in Psychiatric Patients.
Front Psychiatry. 2017 Feb 16;8:25. doi: 10.3389/fpsyt.2017.00025. eCollection 2017.
4
A clinical approach to diagnosis of autoimmune encephalitis.
Lancet Neurol. 2016 Apr;15(4):391-404. doi: 10.1016/S1474-4422(15)00401-9. Epub 2016 Feb 20.
5
Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity.
J Neuropsychiatry Clin Neurosci. 2011 Fall;23(4):425-33. doi: 10.1176/jnp.23.4.jnp425.
7
The expanding clinical profile of anti-AMPA receptor encephalitis.
Neurology. 2010 Mar 9;74(10):857-9. doi: 10.1212/WNL.0b013e3181d3e404.
8
Limbic encephalitis and variants: classification, diagnosis and treatment.
Neurologist. 2007 Sep;13(5):261-71. doi: 10.1097/NRL.0b013e31813e34a5.
9
Autoimmune channelopathies.
Nat Clin Pract Neurol. 2005 Nov;1(1):22-33. doi: 10.1038/ncpneuro0033.

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