电压门控钾通道抗体相关边缘叶脑炎

Voltage-gated potassium channel antibody-associated limbic encephalitis.

作者信息

Saleem Atif, Sophia Rani

机构信息

Medicine, Yeovil District Hospital NHS Foundation Trust, Yeovil District Hospital Higher Kingston, Yeovil, Somerset BA21 4AT, UK.

Medicine (Care of the Elderly), Yeovil District Hospital NHS Foundation Trust, Yeovil, Somerset, UK.

出版信息

Age Ageing. 2014 Jul;43(4):583-5. doi: 10.1093/ageing/afu064. Epub 2014 Jun 6.

DOI:10.1093/ageing/afu064

PMID:24907351

Abstract

We are emphasising the importance of considering a rare diagnosis, voltage-gated Potassium channel antibody-associated limbic encephalitis, in an 80-year-old gentleman who presented with memory impairment, seizure and hyponatraemia. He was found to have high titre of voltage-gated potassium channel antibodies in his serum. He was given high-dose steroids and he responded biochemically and clinically with marked improvement in symptomatology.

摘要

我们强调了在一位80岁男性患者中考虑罕见诊断——电压门控钾通道抗体相关边缘叶脑炎的重要性，该患者出现记忆障碍、癫痫发作和低钠血症。在他的血清中发现了高滴度的电压门控钾通道抗体。他接受了大剂量类固醇治疗，生化指标和临床症状均有改善，症状明显好转。