Yang Chuan-Wei, Li Chia-Ing, Chang Jan-Gowth, Liu Chiu-Shong, Lin Chih-Hsueh, Lin Wen-Yuan, Li Tsai-Chung, Lin Cheng-Chieh
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Geriatr Gerontol Int. 2021 Feb;21(2):166-171. doi: 10.1111/ggi.14105. Epub 2020 Dec 14.
The objective of this study was to explore the association between mitochondrial DNA (mtDNA) haplogroups and physical performances in Han older adults.
This study was an 8-year follow-up prospective cohort study. A total of 104 Han older adults completed the measurements of the 6-min walk test, grip strength and mitochondrial DNA sequencing. The mtDNA haplogroups were classified by using HaploGrep2 software. We used the mixed model to analyze the longitudinal effect of mtDNA haplogroups on physical performance tests among three waves of data.
The mean age at wave 3 among men and women were 78.3 and 77.2 years, respectively. The overall proportions of mtDNA haplogroups in this study population was 26.9% F, 21.2% M, 15.4% R, 14.4% D, 8.7% B and others. After adjusted for age, sex, ethnicity, body mass index and exercise, the interaction of mtDNA haplogroup M and waves significantly affected the 6-min walk distance. Notably, the adjusted mean of the 6-min walk distance among the group of mtDNA haplogroup M was significantly lower than other haplogroups at wave 3. The adjusted mean of grip strength among the group of mtDNA haplogroup R was significantly higher than other haplogroups at wave 3.
This finding suggests that mtDNA haplogroups might have effects on the 6-min walk test and grip strength in Han older adults, although studies of the physical performance of older adults with larger sample sizes are necessary to further substantiate these findings. Geriatr Gerontol Int 2021; 21: 166-171.
本研究旨在探讨线粒体DNA（mtDNA）单倍群与汉族老年人身体机能之间的关联。
本研究为一项为期8年的前瞻性队列研究。共有104名汉族老年人完成了6分钟步行试验、握力测试和线粒体DNA测序。使用HaploGrep2软件对mtDNA单倍群进行分类。我们使用混合模型分析三波数据中mtDNA单倍群对身体机能测试的纵向影响。
第三波时男性和女性的平均年龄分别为78.3岁和77.2岁。本研究人群中mtDNA单倍群的总体比例为F型26.9%、M型21.2%、R型15.4%、D型14.4%、B型8.7%及其他类型。在调整年龄、性别、种族、体重指数和运动因素后，mtDNA单倍群M与波次的交互作用显著影响6分钟步行距离。值得注意的是，在第三波时，mtDNA单倍群M组的6分钟步行距离调整均值显著低于其他单倍群。在第三波时，mtDNA单倍群R组的握力调整均值显著高于其他单倍群。
这一发现表明，mtDNA单倍群可能对汉族老年人的6分钟步行试验和握力有影响，尽管需要对更多样本量的老年人身体机能进行研究，以进一步证实这些发现。《老年医学与老年病学国际杂志》2021年；21: 166 - 171。
