Verma I M, Mitchell R L, Sassone-Corsi P
Salk Institute, San Diego, California 92138.
Princess Takamatsu Symp. 1986;17:279-90.
Proto-oncogene fos is a multifaceted gene, which is expressed during cell growth, cell differentiation, and development. The viral homologue, v-fos, was identified as the resident transforming gene of FBJ-murine osteosarcoma virus which induces bone tumors in mice. Due to an in-fram deletion during the biogenesis of the v-fos gene, the products of viral and cellular fos proteins differ at their C-termini. Despite different C-termini, both fas proteins are nuclear in their location, and can transform fibroblasts in vitro. However, transformation by c-fos gene requires removal of a 67 base pair sequence from the 3' non-coding domain. Proto-oncogene fos is a highly inducible gene in response to a variety of growth factors and differentiation-specific inducers. The transcriptional enhancer and the inducible element of the fos gene have been mapped along with sequences in the 3' non-coding domain which may influence the stability of the c-fos transcripts. The c-fos gene transcription is regulated by positively and negatively acting cellular factors.
原癌基因fos是一个多面性的基因，在细胞生长、细胞分化和发育过程中表达。病毒同源物v-fos被鉴定为FBJ-小鼠骨肉瘤病毒的驻留转化基因，该病毒可在小鼠中诱发骨肿瘤。由于v-fos基因生物合成过程中的框内缺失，病毒和细胞fos蛋白的产物在其C末端有所不同。尽管C末端不同，但两种fas蛋白都位于细胞核内，并且能够在体外转化成纤维细胞。然而，c-fos基因的转化需要从3'非编码区去除一段67个碱基对的序列。原癌基因fos是一个对多种生长因子和分化特异性诱导剂有高度诱导性的基因。fos基因的转录增强子和诱导元件已被定位，同时3'非编码区的序列可能会影响c-fos转录本的稳定性。c-fos基因的转录受正向和负向作用的细胞因子调控。
