Sassone-Corsi P, Verma I M
Nature. 1987;326(6112):507-10. doi: 10.1038/326507a0.
Regulation of transcription in eukaryotes is mediated by the specific interaction between cellular factors and promoter sequences. Cis-acting DNA sequences, frequently located upstream of the TATA box, have been implicated in modulating the expression of many genes. We are interested in the transcriptional regulation of proto-oncogenes because they may have a pivotal function in cell growth and differentiation. Expression of the proto-oncogene c-fos is induced in response to a variety of growth factors and differentiation-specific agents. The viral cognate of the c-fos gene is the resident transforming gene of FBJ-murine osteosarcoma virus which causes bone tumours in vivo and cellular transformation in vitro. We report here that transcription of the human c-fos gene is modulated by negatively and positively acting cellular factors.
真核生物中，转录调控是通过细胞因子与启动子序列之间的特异性相互作用介导的。顺式作用DNA序列通常位于TATA框上游，与许多基因表达的调节有关。我们对原癌基因的转录调控感兴趣，因为它们可能在细胞生长和分化中起关键作用。原癌基因c-fos的表达可被多种生长因子和分化特异性因子诱导。c-fos基因的病毒同源物是FBJ-小鼠骨肉瘤病毒的常驻转化基因，该病毒在体内可引发骨肿瘤，在体外可导致细胞转化。我们在此报告，人类c-fos基因的转录受负性和正性作用的细胞因子调控。
