Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Department of General Surgery, Peking University Third Hospital, Beijing, China.
Cancer Med. 2021 Jan;10(2):737-744. doi: 10.1002/cam4.3644. Epub 2020 Dec 15.
Information on incidence of gastrointestinal stromal tumor (GIST), the most common type of mesenchymal tumor in gastrointestinal tract, was limited in China. This study aimed to estimate the incidence of GIST in urban population from mainland China in 2016.
Urban Employee Basic Medical Insurance (UEBMI) and Urban Residence Basic Medical Insurance (URBMI) in China were used. The denominator of incidence was the total person-years of insured individuals in 2016 in the database, covering approximately 0.43 billion individuals. The numerator was the number of incident GIST cases in 2016.
The crude incidence in 2016 was 0.40 per 100,000 person-years (95% CI, 0.06-1.03). Male incidence was higher than female incidence (0.44 vs. 0.36, rate ratio: 1.22, p < 0.001). The mean age at diagnosis was 55.20 years (SD = 14.26) and the incidence among those aged 50 years or older was 2.63 times (0.84 vs. 0.32, p < 0.001) higher than those aged under 50. The highest incidence was observed in East China (2.29, 95% CI: 0.46-5.54).
The incidence of GIST in mainland China was lower than Europe, North America and Korea. The mean age at diagnosis of GIST in China was younger than that of Europe and Canada. This study provides useful information to further research, policy formulating and management of GIST.
胃肠道间质瘤（GIST）是胃肠道最常见的间叶性肿瘤，中国关于其发病率的信息有限。本研究旨在估计 2016 年中国城市人群 GIST 的发病率。
本研究使用了中国的城镇职工基本医疗保险（UEBMI）和城镇居民基本医疗保险（URBMI）。发病率的分母为数据库中 2016 年参保人员的总人年数，约覆盖 4.3 亿人。分子为 2016 年新发病例数。
2016 年的粗发病率为 0.40/10 万人年（95%CI，0.06-1.03）。男性发病率高于女性（0.44 比 0.36，发病率比：1.22，p<0.001）。诊断时的平均年龄为 55.20 岁（SD=14.26），50 岁及以上人群的发病率是 50 岁以下人群的 2.63 倍（0.84 比 0.32，p<0.001）。华东地区的发病率最高（2.29，95%CI：0.46-5.54）。
中国 GIST 的发病率低于欧洲、北美和韩国。中国 GIST 的诊断平均年龄比欧洲和加拿大小。本研究为进一步研究、制定政策和管理 GIST 提供了有用的信息。
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