Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).
Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China, China (mainland).
Med Sci Monit. 2019 Jul 21;25:5408-5417. doi: 10.12659/MSM.915967.
BACKGROUND Gastrointestinal stromal tumor (GIST) is the most common type of primary gastrointestinal mesenchymal tumor, but GISTs arising in the anus and rectum are rare. This study aimed to undertake a population-based analysis of the incidence, patient demographics, and survival of patients with anorectal GIST compared with patients with GIST arising from other sites based on the Surveillance, Epidemiology, and End Results (SEER) Program database. MATERIAL AND METHODS The SEER database was used to identify all patients diagnosed with GIST and patients diagnosed with anorectal GIST from 2000 to 2015. The incidence of GIST, baseline clinical and demographic data, tumor stage, and patient survival data were analyzed, including overall survival (OS) and cancer-specific survival (CSS). RESULTS A total of 277 patients with anorectal GIST were identified, with an incidence of 0.018 per 100,000. The incidence of GIST arising from other sites was 0.719 per 100,000. The median age at diagnosis for anorectal GIST was 57.5 years (range, 26-92 years), median tumor size was 6.55 cm (range, 0.6-20 cm), and surgery, but not chemotherapy, improved OS and CSS. Patients with anorectal GIST had a mean 1-year, 3-year, 5-year, and 10year OS of 91.1%, 82.5%, 75.2%, and 58.5%, respectively. Patients with GIST arising at other sites had a mean 1-year, 3-year, 5-year, and 10-year OS of 88.3%, 76.4%, 66.5%, and 46.8%, respectively. CONCLUSIONS Anorectal GIST is a rare tumor that has a better outcome compared with GISTs arising at other sites in the gastrointestinal tract.
胃肠道间质瘤（GIST）是最常见的原发性胃肠道间叶肿瘤，但发生在肛门和直肠的 GIST 很少见。本研究旨在根据监测、流行病学和最终结果（SEER）计划数据库，对肛门直肠 GIST 患者与其他部位 GIST 患者的发病率、患者人口统计学和生存情况进行基于人群的分析。
使用 SEER 数据库确定 2000 年至 2015 年间所有诊断为 GIST 和诊断为肛门直肠 GIST 的患者。分析了 GIST 的发病率、基线临床和人口统计学数据、肿瘤分期以及患者生存数据，包括总生存（OS）和癌症特异性生存（CSS）。
共确定 277 例肛门直肠 GIST 患者，发病率为 0.018/10 万。其他部位 GIST 的发病率为 0.719/10 万。肛门直肠 GIST 患者的中位诊断年龄为 57.5 岁（范围为 26-92 岁），中位肿瘤大小为 6.55cm（范围为 0.6-20cm），手术而非化疗可改善 OS 和 CSS。肛门直肠 GIST 患者的 1 年、3 年、5 年和 10 年 OS 分别为 91.1%、82.5%、75.2%和 58.5%。其他部位 GIST 患者的 1 年、3 年、5 年和 10 年 OS 分别为 88.3%、76.4%、66.5%和 46.8%。
肛门直肠 GIST 是一种罕见的肿瘤，其预后优于胃肠道其他部位的 GIST。
