Lau Kieran, Akhavan Behnam, Lord Megan S, Bilek Marcela M, Rnjak-Kovacina Jelena
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
School of Physics, University of Sydney, Sydney, NSW 2006, Australia.
ACS Biomater Sci Eng. 2020 Oct 12;6(10):5431-5452. doi: 10.1021/acsbiomaterials.0c00888. Epub 2020 Sep 9.
Silk-based materials are widely used in biomaterial and tissue engineering applications due to their cytocompatibility and tunable mechanical and biodegradation properties. Aqueous-based processing techniques have enabled the fabrication of silk into a broad range of material formats, making it a highly versatile material platform across multiple industries. Utilizing the full potential of silk in biomedical applications frequently requires modification of silk's surface properties. Dry surface modification techniques, including irradiation and plasma treatment, offer an alternative to the conventional wet chemistry strategies to modify the physical and chemical properties of silk materials without compromising their bulk properties. While dry surface modification techniques are more prevalent in textiles and sterilization applications, the range of modifications available and resultant changes to silk materials all point to the utility of dry surface modification for the development of new, functional silk biomaterials. Dry surface treatment affects the surface chemistry, secondary structure, molecular weight, topography, surface energy, and mechanical properties of silk materials. This Review describes and critically evaluates the effect of physical dry surface modification techniques, including irradiation and plasma processes, on silk materials and discusses their utility in biomedical applications, including recent examples of modulation of cell/protein interactions on silk biomaterials, performance of implanted biomaterials, and applications in material biofunctionalization and lithographic surface patterning approaches.
基于丝绸的材料因其细胞相容性以及可调节的机械和生物降解特性，在生物材料和组织工程应用中被广泛使用。水基加工技术已能够将丝绸制成多种材料形式，使其成为跨多个行业的高度通用的材料平台。在生物医学应用中充分发挥丝绸的潜力通常需要改变丝绸的表面性质。包括辐照和等离子体处理在内的干式表面改性技术，为传统的湿化学策略提供了一种替代方法，可在不影响丝绸材料整体性质的情况下改变其物理和化学性质。虽然干式表面改性技术在纺织品和灭菌应用中更为普遍，但可用的改性范围以及丝绸材料由此产生的变化均表明干式表面改性对于开发新型功能性丝绸生物材料具有实用性。干式表面处理会影响丝绸材料的表面化学、二级结构、分子量、形貌、表面能和机械性能。本综述描述并批判性地评估了包括辐照和等离子体处理在内的物理干式表面改性技术对丝绸材料的影响，并讨论了它们在生物医学应用中的实用性，包括最近在丝绸生物材料上调节细胞/蛋白质相互作用的实例、植入生物材料的性能以及在材料生物功能化和光刻表面图案化方法中的应用。
